Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism

Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson’s disease (PD), we found that reduced SWS quantity in mild parkinsonism was accompanied by elevated beta and reduced delta power during SW...

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Autores principales: Verma, Ajay K., Nandakumar, Bharadwaj, Acedillo, Kit, Yu, Ying, Marshall, Ethan, Schneck, David, Fiecas, Mark, Wang, Jing, MacKinnon, Colum D., Howell, Michael J., Vitek, Jerrold L., Johnson, Luke A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634920/
https://www.ncbi.nlm.nih.gov/pubmed/37961389
http://dx.doi.org/10.1101/2023.10.28.564524
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author Verma, Ajay K.
Nandakumar, Bharadwaj
Acedillo, Kit
Yu, Ying
Marshall, Ethan
Schneck, David
Fiecas, Mark
Wang, Jing
MacKinnon, Colum D.
Howell, Michael J.
Vitek, Jerrold L.
Johnson, Luke A.
author_facet Verma, Ajay K.
Nandakumar, Bharadwaj
Acedillo, Kit
Yu, Ying
Marshall, Ethan
Schneck, David
Fiecas, Mark
Wang, Jing
MacKinnon, Colum D.
Howell, Michael J.
Vitek, Jerrold L.
Johnson, Luke A.
author_sort Verma, Ajay K.
collection PubMed
description Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson’s disease (PD), we found that reduced SWS quantity in mild parkinsonism was accompanied by elevated beta and reduced delta power during SWS in the motor cortex. Our findings support excessive beta oscillations as a mechanism for SWS dysfunction and will inform development of neuromodulation therapies for enhancing SWS in PD.
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spelling pubmed-106349202023-11-13 Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism Verma, Ajay K. Nandakumar, Bharadwaj Acedillo, Kit Yu, Ying Marshall, Ethan Schneck, David Fiecas, Mark Wang, Jing MacKinnon, Colum D. Howell, Michael J. Vitek, Jerrold L. Johnson, Luke A. bioRxiv Article Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson’s disease (PD), we found that reduced SWS quantity in mild parkinsonism was accompanied by elevated beta and reduced delta power during SWS in the motor cortex. Our findings support excessive beta oscillations as a mechanism for SWS dysfunction and will inform development of neuromodulation therapies for enhancing SWS in PD. Cold Spring Harbor Laboratory 2023-11-01 /pmc/articles/PMC10634920/ /pubmed/37961389 http://dx.doi.org/10.1101/2023.10.28.564524 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Verma, Ajay K.
Nandakumar, Bharadwaj
Acedillo, Kit
Yu, Ying
Marshall, Ethan
Schneck, David
Fiecas, Mark
Wang, Jing
MacKinnon, Colum D.
Howell, Michael J.
Vitek, Jerrold L.
Johnson, Luke A.
Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
title Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
title_full Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
title_fullStr Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
title_full_unstemmed Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
title_short Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
title_sort excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634920/
https://www.ncbi.nlm.nih.gov/pubmed/37961389
http://dx.doi.org/10.1101/2023.10.28.564524
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