Decreased fucosylation impacts epithelial integrity and increases risk for COPD

COPD causes significant morbidity and mortality worldwide. Epithelial damage is fundamental to disease pathogenesis, although the mechanisms driving disease remain undefined. Published evidence from a COPD cohort (SPIROMICS) and confirmed in a second cohort (COPDgene) demonstrate a polymorphism in F...

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Detalles Bibliográficos
Autores principales: Swaby, Carter, Yeung-Luk, Bonnie, Thapa, Shreeti, Nishida, Kristine, Wally, Arabelis, Ghosh, Baishakhi, Niederkofler, Austin, Luk, Sean, Girgis, Mirit, Keller, Allison, Cortez, Cecilia, Ramaswamy, Sahana, Wilmsen, Kai, Bouché, Laura, Dell, Anne, Drummond, M. Bradley, Putcha, Nirupama, Haslam, Stuart M., Mathias, Rasika, Hansel, Nadia N., Sheng, Jian, Sidhaye, Venkataramana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635007/
https://www.ncbi.nlm.nih.gov/pubmed/37961411
http://dx.doi.org/10.1101/2023.10.31.564805

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