Lac-Phe mediates the anti-obesity effect of metformin

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. The mechanisms that mediate metformin’s effects on energy balance remain incompletely defined. Here we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite Lac-Phe in mice as we...

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Detalles Bibliográficos
Autores principales: Xiao, Shuke, Li, Veronica L., Lyu, Xuchao, Chen, Xudong, Wei, Wei, Abbasi, Fahim, Knowles, Joshua W., Deng, Shuliang, Tiwari, Gaurav, Shi, Xu, Zheng, Shuning, Farrell, Laurie, Chen, Zsu-Zsu, Taylor, Kent D., Guo, Xiuqing, Goodarzi, Mark O., Wood, Alexis C., Ida Chen, Yii-Der, Lange, Leslie A., Rich, Stephen S., Rotter, Jerome I., Clish, Clary B., Tahir, Usman A., Gerszten, Robert E., Benson, Mark D., Long, Jonathan Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635077/
https://www.ncbi.nlm.nih.gov/pubmed/37961394
http://dx.doi.org/10.1101/2023.11.02.565321

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