Cargando…

Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma

Merkel Cell Carcinoma (MCC) is a highly aggressive neuroendocrine cutaneous malignancy arising from either ultraviolet-induced mutagenesis or Merkel cell polyomavirus (MCPyV) integration. It is the only known neuroendocrine tumor (NET) with a virus etiology. Despite extensive research, our understan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Jiawen, Lim, James T, Victor, Paul, Chen, Chen, Khwaja, Hunain, Schnellmann, Rick G, Roe, Denise J, Gokhale, Prafulla C, DeCaprio, James A, Padi, Megha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635082/ https://www.ncbi.nlm.nih.gov/pubmed/37961132 http://dx.doi.org/10.1101/2023.11.01.565218

Ejemplares similares

Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads
por: Gunderson, Emma L., et al.
Publicado: (2022)

The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer
por: Xu, Wei, et al.
Publicado: (2013)

Pyrvinium Pamoate: Past, Present, and Future as an Anti-Cancer Drug
por: Schultz, Christopher W., et al.
Publicado: (2022)

Pyrvinium pamoate can overcome artemisinin’s resistance in anaplastic thyroid cancer
por: Li, Yitian
Publicado: (2021)

Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo
por: Li, Yali, et al.
Publicado: (2022)

Synergistic Effect of Pyrvinium Pamoate and Azoles Against Aspergillus fumigatus in vitro and in vivo
por: Sun, Yi, et al.
Publicado: (2020)

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration
por: Ishii, Isao, et al.
Publicado: (2012)

Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells
por: Xu, Fang, et al.
Publicado: (2020)

Identification of pyrvinium pamoate as an anti-tuberculosis agent in vitro and in vivo by SOSA approach amongst known drugs
por: Guan, Qing, et al.
Publicado: (2020)

Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer
por: Zheng, Wenqian, et al.
Publicado: (2021)

Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure
por: Shen, Manli, et al.
Publicado: (2013)

In vitro and in vivo Study of Antifungal Effect of Pyrvinium Pamoate Alone and in Combination With Azoles Against Exophiala dermatitidis
por: Sun, Yi, et al.
Publicado: (2020)

P007 Fumaric reductase analog regulates sensitivity of pyrvinium pamoate and voriconazoole against Exophiala Dermatiti dis
por: Li, Xiaotong, et al.
Publicado: (2022)

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation
por: Berrios, Christian, et al.
Publicado: (2016)

Pyrvinium pamoate regulates MGMT expression through suppressing the Wnt/β-catenin signaling pathway to enhance the glioblastoma sensitivity to temozolomide
por: Li, Haisong, et al.
Publicado: (2021)

An Anthelmintic Drug, Pyrvinium Pamoate, Thwarts Fibrosis and Ameliorates Myocardial Contractile Dysfunction in a Mouse Model of Myocardial Infarction
por: Murakoshi, Motoaki, et al.
Publicado: (2013)

Lipidomic Analyses Uncover Apoptotic and Inhibitory Effects of Pyrvinium Pamoate on Cholangiocarcinoma Cells via Mitochondrial Membrane Potential Dysfunction
por: Kittirat, Yingpinyapat, et al.
Publicado: (2021)

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks
por: Fischer, Martin, et al.
Publicado: (2016)

Deciphering the Role of Pyrvinium Pamoate in the Generation of Integrated Stress Response and Modulation of Mitochondrial Function in Myeloid Leukemia Cells through Transcriptome Analysis
por: Fu, Yu-Hsuan, et al.
Publicado: (2021)

Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs
por: Enkai, Shigehiro, et al.
Publicado: (2020)

High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia
por: Wander, Priscilla, et al.
Publicado: (2021)

Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma
por: Ananthapadmanabhan, Varsha, et al.
Publicado: (2022)

Merkel Cell Polyomavirus: Oncogenesis in a Stable Genome
por: Ahmed, Mona M., et al.
Publicado: (2021)

Does a new polyomavirus contribute to Merkel cell carcinoma?
por: Garneski, Kelly M, et al.
Publicado: (2008)

Repurposing the FDA-approved anthelmintic pyrvinium pamoate for pancreatic cancer treatment: study protocol for a phase I clinical trial in early-stage pancreatic ductal adenocarcinoma
por: Ponzini, Francesca M, et al.
Publicado: (2023)

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis
por: Cheng, Jingwei, et al.
Publicado: (2017)

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis
por: Park, Donglim Esther, et al.
Publicado: (2020)

The Merkel Cell Polyomavirus T Antigens Function as Tumor Promoters in Murine Skin
por: Spurgeon, Megan E., et al.
Publicado: (2021)

Predictors of immunotherapy benefit in Merkel cell carcinoma
por: Kacew, Alec J., et al.
Publicado: (2020)

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities
por: Harms, Paul W., et al.
Publicado: (2018)

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma
por: Starrett, Gabriel J., et al.
Publicado: (2017)

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development
por: Spurgeon, Megan E., et al.
Publicado: (2022)

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes
por: Müller, Gerd A., et al.
Publicado: (2012)

An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response
por: Knepper, Todd C., et al.
Publicado: (2021)

Pyrvinium doubles against WNT-driven cancer
por: Fan, Jiaming, et al.
Publicado: (2022)

Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain Inhibitor Pyrvinium
por: Pal, Sumanta K., et al.
Publicado: (2019)

YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma
por: Frost, Thomas C., et al.
Publicado: (2023)

Pyrvinium targets autophagy addiction to promote cancer cell death
por: Deng, Longfei, et al.
Publicado: (2013)

Long-acting injectable antipsychotics: focus on olanzapine pamoate
por: Lindenmayer, JP
Publicado: (2010)

Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota
por: Schneeberger, Pierre H.H., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_khv2phhkgfsk2inikq8b341j6k