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The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

The human papillomavirus (HPV) oncoprotein E7 is a relatively short-lived protein required for HPV-driven cancer development and maintenance. E7 is degraded through ubiquitination mediated by cullin 1 (CUL1) and the ubiquitin-conjugating enzyme E2 L3 (UBE2L3). However, E7 proteins are maintained at...

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Detalles Bibliográficos
Autores principales:	Khalil, Mohamed I., Yang, Canchai, Vu, Lexi, Chadha, Smriti, Nabors, Harrison, James, Claire D., Morgan, Iain M., Pyeon, Dohun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635129/ https://www.ncbi.nlm.nih.gov/pubmed/37961092 http://dx.doi.org/10.1101/2023.11.03.565564

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