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Purinergic calcium signaling drives drug tolerance through ERK reactivation in BRAF-mutant melanoma
We report a previously unrecognized signaling mechanism underlying drug tolerance in BRAF-mutant melanoma treated with BRAF inhibitors. Its key feature is sustained intracellular Ca(2+) signaling initiated by purinergic ligand-gated cation channels, P2X receptors. Src family kinases act as mediators...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635130/ https://www.ncbi.nlm.nih.gov/pubmed/37961267 http://dx.doi.org/10.1101/2023.11.03.565532 |