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Aryl hydrocarbon receptor restricts axon regeneration of DRG neurons in response to injury

Injured neurons sense environmental cues to balance neural protection and axon regeneration, but the mechanisms are unclear. Here, we unveil aryl hydrocarbon receptor (AhR), a ligand-activated bHLH-PAS transcription factor, as molecular sensor and key regulator of acute stress response at the expens...

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Detalles Bibliográficos
Autores principales: Wang, Yiqun, Halawani, Dalia, Estill, Molly, Ramakrishnan, Aarthi, Shen, Li, Friedel, Roland H., Zou, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635160/
https://www.ncbi.nlm.nih.gov/pubmed/37961567
http://dx.doi.org/10.1101/2023.11.04.565649