Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms

BACKGROUND: Frailty is a geriatric syndrome characterized by chronic inflammation and metabolic insufficiency that creates vulnerability to poor outcomes with aging. We hypothesize that geroscience interventions, which target mechanisms of aging, could ameliorate frailty. Metabolites such as ketone...

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Detalles Bibliográficos
Autores principales: Stubbs, Brianna. J, Alvarez-Azanedo, Gabriela, Peralta, Sawyer, Roa-Diaz, Stephanie, Gray, Wyatt, Alexander, Laura, Silverman-Martin, Wendie, Garcia, Thelma, Blonquist, Traci M., Upadhyay, Vaibhav, Turnbaugh, Peter J., Johnson, James B., Newman, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635199/
https://www.ncbi.nlm.nih.gov/pubmed/37961234
http://dx.doi.org/10.1101/2023.10.25.23297571

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