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Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity

For antigenically variable pathogens such as influenza, strain fitness is partly determined by the relative availability of hosts susceptible to infection with that strain compared to others. Antibodies to the hemagglutinin (HA) and neuraminidase (NA) confer substantial protection against influenza...

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Autores principales: Kim, Kangchon, Gouma, Sigrid, Vieira, Marcos C., Weirick, Madison E., Hensley, Scott E., Cobey, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635207/
https://www.ncbi.nlm.nih.gov/pubmed/37961288
http://dx.doi.org/10.1101/2023.10.26.23297569
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author Kim, Kangchon
Gouma, Sigrid
Vieira, Marcos C.
Weirick, Madison E.
Hensley, Scott E.
Cobey, Sarah
author_facet Kim, Kangchon
Gouma, Sigrid
Vieira, Marcos C.
Weirick, Madison E.
Hensley, Scott E.
Cobey, Sarah
author_sort Kim, Kangchon
collection PubMed
description For antigenically variable pathogens such as influenza, strain fitness is partly determined by the relative availability of hosts susceptible to infection with that strain compared to others. Antibodies to the hemagglutinin (HA) and neuraminidase (NA) confer substantial protection against influenza infection. We asked if a cross-sectional antibody-derived estimate of population susceptibility to different clades of influenza A (H3N2) could predict the success of clades in the following season. We collected sera from 483 healthy individuals aged 1 to 90 years in the summer of 2017 and analyzed neutralizing responses to the HA and NA of representative strains. The clade to which neutralizing antibody titers were lowest, indicating greater population susceptibility, dominated the next season. Titers to different HA and NA clades varied dramatically between individuals but showed significant associations with age, suggesting dependence on correlated past exposures. Despite this correlation, inter-individual variability in antibody titers to H3N2 strains increased gradually with age. This study indicates how representative measures of population immunity might improve evolutionary forecasts and inform selective pressures on influenza.
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spelling pubmed-106352072023-11-13 Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity Kim, Kangchon Gouma, Sigrid Vieira, Marcos C. Weirick, Madison E. Hensley, Scott E. Cobey, Sarah medRxiv Article For antigenically variable pathogens such as influenza, strain fitness is partly determined by the relative availability of hosts susceptible to infection with that strain compared to others. Antibodies to the hemagglutinin (HA) and neuraminidase (NA) confer substantial protection against influenza infection. We asked if a cross-sectional antibody-derived estimate of population susceptibility to different clades of influenza A (H3N2) could predict the success of clades in the following season. We collected sera from 483 healthy individuals aged 1 to 90 years in the summer of 2017 and analyzed neutralizing responses to the HA and NA of representative strains. The clade to which neutralizing antibody titers were lowest, indicating greater population susceptibility, dominated the next season. Titers to different HA and NA clades varied dramatically between individuals but showed significant associations with age, suggesting dependence on correlated past exposures. Despite this correlation, inter-individual variability in antibody titers to H3N2 strains increased gradually with age. This study indicates how representative measures of population immunity might improve evolutionary forecasts and inform selective pressures on influenza. Cold Spring Harbor Laboratory 2023-10-27 /pmc/articles/PMC10635207/ /pubmed/37961288 http://dx.doi.org/10.1101/2023.10.26.23297569 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Kim, Kangchon
Gouma, Sigrid
Vieira, Marcos C.
Weirick, Madison E.
Hensley, Scott E.
Cobey, Sarah
Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity
title Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity
title_full Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity
title_fullStr Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity
title_full_unstemmed Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity
title_short Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity
title_sort measures of population immunity can predict the dominant clade of influenza a (h3n2) and reveal age-associated differences in susceptibility and specificity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635207/
https://www.ncbi.nlm.nih.gov/pubmed/37961288
http://dx.doi.org/10.1101/2023.10.26.23297569
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