Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications

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Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~7–8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to identify patients who harbor CRC field carcinogenesis by evaluating chromatin 3D architecture. Supranucleosomal disorde...

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Detalles Bibliográficos
Autores principales: Chang, Andrew, Prabhala, Sravya, Daneshkhah, Ali, Lin, Jianan, Subramanian, Hariharan, Roy, Hemant Kumar, Backman, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635240/
https://www.ncbi.nlm.nih.gov/pubmed/37961299
http://dx.doi.org/10.1101/2023.10.30.23297790
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