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scX: A user-friendly tool for scRNA-seq exploration

Single-cell RNA sequencing (scRNAseq) has revolutionized our ability to explore biological systems by enabling the study of gene expression at the individual cell level. However, handling and analyzing this data often require specialized expertise. In this contribution, we present scX, an R package...

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Autores principales: Waichman, Tomás Vega, Vercesi, M. Luz, Berardino, Ariel A., Beckel, Maximiliano S., Giacomini, Damiana, Rasetto, Natalí B., Herrero, Magalí, Bella, Daniela J. Di, Arlotta, Paola, Schinder, Alejandro F., Chernomoretz, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornell University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635291/
https://www.ncbi.nlm.nih.gov/pubmed/37961742
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author Waichman, Tomás Vega
Vercesi, M. Luz
Berardino, Ariel A.
Beckel, Maximiliano S.
Giacomini, Damiana
Rasetto, Natalí B.
Herrero, Magalí
Bella, Daniela J. Di
Arlotta, Paola
Schinder, Alejandro F.
Chernomoretz, Ariel
author_facet Waichman, Tomás Vega
Vercesi, M. Luz
Berardino, Ariel A.
Beckel, Maximiliano S.
Giacomini, Damiana
Rasetto, Natalí B.
Herrero, Magalí
Bella, Daniela J. Di
Arlotta, Paola
Schinder, Alejandro F.
Chernomoretz, Ariel
author_sort Waichman, Tomás Vega
collection PubMed
description Single-cell RNA sequencing (scRNAseq) has revolutionized our ability to explore biological systems by enabling the study of gene expression at the individual cell level. However, handling and analyzing this data often require specialized expertise. In this contribution, we present scX, an R package built on top of the Shiny framework, designed to simplify the analysis, exploration, and visualization of single-cell experiments. scX offers straightforward access to essential scRNAseq analyses, encompassing marker identification, gene expression profiling, and differential gene expression analysis. Implemented as a local web application with an intuitive graphical interface, scX allows users to create customized, publication-ready plots. Additionally, it seamlessly integrates with popular single-cell Seurat and SingleCellExperiment R objects, facilitating the rapid processing and visualization of diverse datasets. In summary, scX serves as a valuable tool for effortless exploration and sharing of single-cell data, alleviating some of the complexities associated with scRNAseq analysis.
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spelling pubmed-106352912023-11-13 scX: A user-friendly tool for scRNA-seq exploration Waichman, Tomás Vega Vercesi, M. Luz Berardino, Ariel A. Beckel, Maximiliano S. Giacomini, Damiana Rasetto, Natalí B. Herrero, Magalí Bella, Daniela J. Di Arlotta, Paola Schinder, Alejandro F. Chernomoretz, Ariel ArXiv Article Single-cell RNA sequencing (scRNAseq) has revolutionized our ability to explore biological systems by enabling the study of gene expression at the individual cell level. However, handling and analyzing this data often require specialized expertise. In this contribution, we present scX, an R package built on top of the Shiny framework, designed to simplify the analysis, exploration, and visualization of single-cell experiments. scX offers straightforward access to essential scRNAseq analyses, encompassing marker identification, gene expression profiling, and differential gene expression analysis. Implemented as a local web application with an intuitive graphical interface, scX allows users to create customized, publication-ready plots. Additionally, it seamlessly integrates with popular single-cell Seurat and SingleCellExperiment R objects, facilitating the rapid processing and visualization of diverse datasets. In summary, scX serves as a valuable tool for effortless exploration and sharing of single-cell data, alleviating some of the complexities associated with scRNAseq analysis. Cornell University 2023-10-31 /pmc/articles/PMC10635291/ /pubmed/37961742 Text en https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
spellingShingle Article
Waichman, Tomás Vega
Vercesi, M. Luz
Berardino, Ariel A.
Beckel, Maximiliano S.
Giacomini, Damiana
Rasetto, Natalí B.
Herrero, Magalí
Bella, Daniela J. Di
Arlotta, Paola
Schinder, Alejandro F.
Chernomoretz, Ariel
scX: A user-friendly tool for scRNA-seq exploration
title scX: A user-friendly tool for scRNA-seq exploration
title_full scX: A user-friendly tool for scRNA-seq exploration
title_fullStr scX: A user-friendly tool for scRNA-seq exploration
title_full_unstemmed scX: A user-friendly tool for scRNA-seq exploration
title_short scX: A user-friendly tool for scRNA-seq exploration
title_sort scx: a user-friendly tool for scrna-seq exploration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635291/
https://www.ncbi.nlm.nih.gov/pubmed/37961742
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