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Integration of persistent Laplacian and pre-trained transformer for protein solubility changes upon mutation
Protein mutations can significantly influence protein solubility, which results in altered protein functions and leads to various diseases. Despite of tremendous effort, machine learning prediction of protein solubility changes upon mutation remains a challenging task as indicated by the poor scores...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cornell University
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635294/ https://www.ncbi.nlm.nih.gov/pubmed/37961732 |