Cargando…

Senescent and disease-associated microglia are modifiable features of aged brain white matter

Brain white matter tracts undergo structural and functional changes linked to late-life cognitive decline, but the cellular and molecular contributions to their selective vulnerability are not well defined. In naturally aged mice, we demonstrate that senescent and disease-associated microglia (DAM)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carver, Chase M., Gomez, Paul T., Rodriguez, Sonia L., Kachergus, Jennifer M., Liu, Yi, Shi, Ji, Tran, Tommy, Wang, Liguo, Melov, Simon, Thompson, E. Aubrey, Schafer, Marissa J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635389/ https://www.ncbi.nlm.nih.gov/pubmed/37961365 http://dx.doi.org/10.21203/rs.3.rs-3467812/v1

Ejemplares similares

SPATIALLY RESOLVED MAPPING OF CELL-SPECIFIC SENESCENT PROFILES IN AGING MOUSE BRAIN
por: Carver, Chase, et al.
Publicado: (2022)

CELL SENESCENCE IS A FEATURE AND MODULATOR OF THE AGED INFLAMMATORY BRAIN CELL LANDSCAPE
por: Schafer, Marissa, et al.
Publicado: (2022)

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype
por: Matsudaira, Tatsuyuki, et al.
Publicado: (2023)

Comparative Aspects of Microglia Reaction in White and Gray Matter
por: Cătălin, B., et al.
Publicado: (2013)

Unique microglia expression profile in developing white matter
por: Staszewski, Ori, et al.
Publicado: (2019)

Heterogeneity of microglia and their differential roles in white matter pathology
por: Lee, Janice, et al.
Publicado: (2019)

Loss of USP18 in microglia induces white matter pathology
por: Schwabenland, Marius, et al.
Publicado: (2019)

SENESCENCE AND INFLAMMATION
por: Schafer, Marissa
Publicado: (2022)

Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages
por: Gao, Xinjie, et al.
Publicado: (2022)

Ultrastructural pathology of oligodendrocytes adjacent to microglia in prefrontal white matter in schizophrenia
por: Uranova, Natalya A., et al.
Publicado: (2018)

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories
por: Gefen, Tamar, et al.
Publicado: (2019)

The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia
por: Sirkis, Daniel W, et al.
Publicado: (2021)

Iba-1(-)/CD68(+) microglia are a prominent feature of age-associated deep subcortical white matter lesions
por: Waller, Rachel, et al.
Publicado: (2019)

AN OPTIMIZED MOUSE PARABIOSIS PROTOCOL FOR INVESTIGATION OF AGING AND REJUVENATIVE MECHANISMS
por: Rodriguez, Sonia, et al.
Publicado: (2022)

Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal
por: Kuehnemann, Chisaka, et al.
Publicado: (2022)

Senescent Microglia: The Key to the Ageing Brain?
por: Greenwood, Eleanor K., et al.
Publicado: (2021)

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance
por: Zhang, Xu, et al.
Publicado: (2022)

Significance and In Vivo Detection of Iron-Laden Microglia in White Matter Multiple Sclerosis Lesions
por: Gillen, Kelly M., et al.
Publicado: (2018)

CD8(+) T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging
por: Kaya, Tuğberk, et al.
Publicado: (2022)

CD11c(+) microglia promote white matter repair after ischemic stroke
por: Jia, Junqiu, et al.
Publicado: (2023)

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
por: van Horssen, Jack, et al.
Publicado: (2012)

Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging
por: Yin, Zhuoran, et al.
Publicado: (2018)

Association of white matter hyperintensities with migraine features and prognosis
por: Xie, Hui, et al.
Publicado: (2018)

Microglia activation mediated by toll-like receptor-4 impairs brain white matter tracts in rats
por: Yang, Xinglong, et al.
Publicado: (2018)

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
por: van der Poel, Marlijn, et al.
Publicado: (2019)

Microglial SIRPα regulates the emergence of CD11c(+) microglia and demyelination damage in white matter
por: Sato-Hashimoto, Miho, et al.
Publicado: (2019)

Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
por: Krishnan, Michelle L., et al.
Publicado: (2017)

Microglia: Newly discovered complexity could lead to targeted therapy for neonatal white matter injury and dysmaturation
por: Volpe, J.J.
Publicado: (2019)

Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination
por: Zheng, Jingwei, et al.
Publicado: (2021)

Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain
por: Picone, Pasquale, et al.
Publicado: (2021)

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave
por: Hohsfield, Lindsay A, et al.
Publicado: (2021)

Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV
por: Hsiao, Chiu-Bin, et al.
Publicado: (2021)

White Matter Injury of Prematurity: Its Mechanisms and Clinical Features
por: Lee, Young Ah
Publicado: (2017)

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators
por: Fowler, Jill H, et al.
Publicado: (2017)

Viscoelastic properties of white and gray matter-derived microglia differentiate upon treatment with lipopolysaccharide but not upon treatment with myelin
por: van Wageningen, Thecla A., et al.
Publicado: (2021)

SENESCENCE-ASSOCIATED SECRETOME COMPONENTS AS BIOMARKERS FOR AGING
por: Zhang, Xu, et al.
Publicado: (2019)

APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts
por: Weishaupt, Nina, et al.
Publicado: (2018)

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice
por: Decoeur, Fanny, et al.
Publicado: (2022)

Microglia activation in periplaque white matter in multiple sclerosis depends on age and lesion type, but does not correlate with oligodendroglial loss
por: Kessler, Wiebke, et al.
Publicado: (2023)

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
por: Hu, Yanling, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_iog6oers96ou2f7sn94eq3kuno