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Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history

Brain metastases are a frequent occurrence in neuropathology practices. The literature on their neuroanatomical location is frequently derived from radiological analyses. This work examines brain metastases through the lens of pathology specimens. All brain surgical pathology reports for cases acces...

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Autores principales: Bonert, Michael, Berzins, Alison, Begum, Housne, Schittenhelm, Jens, Lu, Jian-Qiang, Juergens, Rosalyn A., Swaminath, Anand, Cutz, Jean-Claude, Naqvi, Asghar H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635465/
https://www.ncbi.nlm.nih.gov/pubmed/37943775
http://dx.doi.org/10.1371/journal.pone.0294154
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author Bonert, Michael
Berzins, Alison
Begum, Housne
Schittenhelm, Jens
Lu, Jian-Qiang
Juergens, Rosalyn A.
Swaminath, Anand
Cutz, Jean-Claude
Naqvi, Asghar H.
author_facet Bonert, Michael
Berzins, Alison
Begum, Housne
Schittenhelm, Jens
Lu, Jian-Qiang
Juergens, Rosalyn A.
Swaminath, Anand
Cutz, Jean-Claude
Naqvi, Asghar H.
author_sort Bonert, Michael
collection PubMed
description Brain metastases are a frequent occurrence in neuropathology practices. The literature on their neuroanatomical location is frequently derived from radiological analyses. This work examines brain metastases through the lens of pathology specimens. All brain surgical pathology reports for cases accessioned 2011–2020 were retrieved from a laboratory. Specimens were classified by neuroanatomical location, diagnosis and diagnostic category with a hierarchical free text string-matching algorithm (HFTSMA) and also subsequently audited. All reports classified as probable metastasis were reviewed by a pathologist. The provided history was compared to the final categorization by a pathologist. The cohort had 4,625 cases. The HFTSMA identified 854 cases (including metastases from a definite primary, metastases from primary not known and improperly classified cases). 514/854 cases had one definite primary site per algorithm and on report review 538/854 cases were confirmed as such. The 538 cases originated from 511 patients. Primaries from breast, gynecologic tract, and gastrointestinal tract not otherwise specified were most frequently found in the cerebellum. Kidney metastases were most frequently found in the occipital lobe. Lung, metastatic melanoma and colorectal primaries were most commonly found in the frontal lobe. The provided clinical history predicted the primary in 206 cases (40.3%), was discordant in 17 cases (3.3%) and non-contributory in 280 cases (54.8%). The observed distribution of the metastatic tumours in the brain is dependent on the primary site. In the majority (54.8%) of cases, the provided clinical history was non-contributory; this suggests surgeon-pathologist communication may have the potential for optimization.
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spelling pubmed-106354652023-11-10 Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history Bonert, Michael Berzins, Alison Begum, Housne Schittenhelm, Jens Lu, Jian-Qiang Juergens, Rosalyn A. Swaminath, Anand Cutz, Jean-Claude Naqvi, Asghar H. PLoS One Research Article Brain metastases are a frequent occurrence in neuropathology practices. The literature on their neuroanatomical location is frequently derived from radiological analyses. This work examines brain metastases through the lens of pathology specimens. All brain surgical pathology reports for cases accessioned 2011–2020 were retrieved from a laboratory. Specimens were classified by neuroanatomical location, diagnosis and diagnostic category with a hierarchical free text string-matching algorithm (HFTSMA) and also subsequently audited. All reports classified as probable metastasis were reviewed by a pathologist. The provided history was compared to the final categorization by a pathologist. The cohort had 4,625 cases. The HFTSMA identified 854 cases (including metastases from a definite primary, metastases from primary not known and improperly classified cases). 514/854 cases had one definite primary site per algorithm and on report review 538/854 cases were confirmed as such. The 538 cases originated from 511 patients. Primaries from breast, gynecologic tract, and gastrointestinal tract not otherwise specified were most frequently found in the cerebellum. Kidney metastases were most frequently found in the occipital lobe. Lung, metastatic melanoma and colorectal primaries were most commonly found in the frontal lobe. The provided clinical history predicted the primary in 206 cases (40.3%), was discordant in 17 cases (3.3%) and non-contributory in 280 cases (54.8%). The observed distribution of the metastatic tumours in the brain is dependent on the primary site. In the majority (54.8%) of cases, the provided clinical history was non-contributory; this suggests surgeon-pathologist communication may have the potential for optimization. Public Library of Science 2023-11-09 /pmc/articles/PMC10635465/ /pubmed/37943775 http://dx.doi.org/10.1371/journal.pone.0294154 Text en © 2023 Bonert et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bonert, Michael
Berzins, Alison
Begum, Housne
Schittenhelm, Jens
Lu, Jian-Qiang
Juergens, Rosalyn A.
Swaminath, Anand
Cutz, Jean-Claude
Naqvi, Asghar H.
Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history
title Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history
title_full Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history
title_fullStr Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history
title_full_unstemmed Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history
title_short Neuroanatomical location of brain metastases from solid tumours based on pathology: An analysis of 511 patients with a comparison to the provided clinical history
title_sort neuroanatomical location of brain metastases from solid tumours based on pathology: an analysis of 511 patients with a comparison to the provided clinical history
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635465/
https://www.ncbi.nlm.nih.gov/pubmed/37943775
http://dx.doi.org/10.1371/journal.pone.0294154
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