Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth

Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting Wnt signaling pathways reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by the side effect. Inhibitors targeting specific Wnt-F...

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Detalles Bibliográficos
Autores principales: He, Aina, Tian, Songhai, Kopper, Oded, Horan, Daniel J., Chen, Peng, Bronson, Roderick T., Sheng, Ren, Wu, Hao, Sui, Lufei, Zhou, Kun, Tao, Liang, Wu, Quan, Huang, Yujing, Shen, Zan, Han, Sen, Chen, Xueqing, Chen, Hong, He, Xi, Robling, Alexander G., Jin, Rongsheng, Clevers, Hans, Xiang, Dongxi, Li, Zhe, Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635564/
https://www.ncbi.nlm.nih.gov/pubmed/37943878
http://dx.doi.org/10.1371/journal.pbio.3002353

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