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Allosteric regulation of kinase activity in living cells
The dysregulation of protein kinases is associated with multiple diseases due to the kinases' involvement in a variety of cell signaling pathways. Manipulating protein kinase function, by controlling the active site, is a promising therapeutic and investigative strategy to mitigate and study di...
Autores principales: | Godbole, Shivani Sujay, Dokholyan, Nikolay V |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635643/ https://www.ncbi.nlm.nih.gov/pubmed/37943025 http://dx.doi.org/10.7554/eLife.90574 |
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