Polyploid tubular cells initiate a TGF-β1 controlled loop that sustains polyploidization and fibrosis after acute kidney injury

Polyploidization of tubular cells (TC) is triggered by acute kidney injury (AKI) to allow survival in the early phase after AKI, but in the long run promotes fibrosis and AKI-chronic kidney disease (CKD) transition. The molecular mechanism governing the link between polyploid TC and kidney fibrosis...

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Detalles Bibliográficos
Autores principales: De Chiara, Letizia, Semeraro, Roberto, Mazzinghi, Benedetta, Landini, Samuela, Molli, Alice, Antonelli, Giulia, Angelotti, Maria Lucia, Melica, Maria Elena, Maggi, Laura, Conte, Carolina, Peired, Anna Julie, Cirillo, Luigi, Raglianti, Valentina, Magi, Alberto, Annunziato, Francesco, Romagnani, Paola, Lazzeri, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635654/
https://www.ncbi.nlm.nih.gov/pubmed/37642236
http://dx.doi.org/10.1152/ajpcell.00081.2023

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