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Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes

Metformin-induced glycolysis and lactate production can lead to acidosis as a life-threatening side effect, but slight increases in blood lactate levels in a physiological range were also reported in metformin-treated patients. However, how metformin increases systemic lactate concentrations is only...

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Detalles Bibliográficos
Autores principales:	Maurer, Jennifer, Zhao, Xinjie, Irmler, Martin, Gudiksen, Anders, Pilmark, Nanna S., Li, Qi, Goj, Thomas, Beckers, Johannes, Hrabě de Angelis, Martin, Birkenfeld, Andreas L., Peter, Andreas, Lehmann, Rainer, Pilegaard, Henriette, Karstoft, Kristian, Xu, Guowang, Weigert, Cora
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635655/ https://www.ncbi.nlm.nih.gov/pubmed/37694284 http://dx.doi.org/10.1152/ajpcell.00186.2023

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