Cargando…

Renal dysfunction and outcome in left ventricular non-compaction

BACKGROUND: While renal function has been observed to inversely correlate with clinical outcome in other cardiomyopathies, its prognostic significance in patients with left ventricular non-compaction cardiomyopathy (LVNC) has not been investigated. The aim of this study was to determine the prognost...

Descripción completa

Detalles Bibliográficos
Autores principales: Erhart, Ladina, Kaufmann, Beat A., Gencer, Baris, Haager, Philipp K., Müller, Hajo, Kobza, Richard, Held, Leonhard, Stämpfli, Simon F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Via Medica 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635721/
https://www.ncbi.nlm.nih.gov/pubmed/36385602
http://dx.doi.org/10.5603/CJ.a2022.0105
_version_ 1785146353292148736
author Erhart, Ladina
Kaufmann, Beat A.
Gencer, Baris
Haager, Philipp K.
Müller, Hajo
Kobza, Richard
Held, Leonhard
Stämpfli, Simon F.
author_facet Erhart, Ladina
Kaufmann, Beat A.
Gencer, Baris
Haager, Philipp K.
Müller, Hajo
Kobza, Richard
Held, Leonhard
Stämpfli, Simon F.
author_sort Erhart, Ladina
collection PubMed
description BACKGROUND: While renal function has been observed to inversely correlate with clinical outcome in other cardiomyopathies, its prognostic significance in patients with left ventricular non-compaction cardiomyopathy (LVNC) has not been investigated. The aim of this study was to determine the prognostic value of renal function in LVNC patients. METHODS: Patients with isolated LVNC as diagnosed by echocardiography and/or magnetic resonance imaging in 4 Swiss centers were retrospectively analyzed for this study. Values for creatinine, urea, and estimated glomerular filtration rate (eGFR) as assessed by the CKD-EPI 2009 formula were collected and analyzed by a Cox regression model for the occurrence of a composite endpoint (death or heart transplantation). RESULTS: During the median observation period of 7.4 years 23 patients reached the endpoint. The age-and gender-corrected hazard ratios (HR) for death or heart transplantation were: 1.9 (95% confidence interval [CI] 1.4–2.6) for each increase over baseline creatinine level of 30 μmol/L (p < 0.001), 1.6 (95% CI 1.2–2.2) for each increase over baseline urea level of 5 mmol/L (p = 0.004), and 3.6 (95% CI 1.9–6.9) for each decrease below baseline eGFR level of 30 mL/min (p ≤ 0.001). The HR (log2) for every doubling of creatinine was 7.7 (95% CI 3–19.8; p < 0.001), for every doubling of urea 2.5 (95% CI 1.5–4.3; p < 0.001), and for every bisection of eGFR 5.3 (95% CI 2.4–11.6; p < 0.001). CONCLUSIONS: This study provides evidence that in patients with LVNC impairment in renal function is associated with an increased risk of death and heart transplantation suggesting that kidney function assessment should be standard in risk assessment of LVNC patients.
format Online
Article
Text
id pubmed-10635721
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Via Medica
record_format MEDLINE/PubMed
spelling pubmed-106357212023-11-15 Renal dysfunction and outcome in left ventricular non-compaction Erhart, Ladina Kaufmann, Beat A. Gencer, Baris Haager, Philipp K. Müller, Hajo Kobza, Richard Held, Leonhard Stämpfli, Simon F. Cardiol J Clinical Cardiology BACKGROUND: While renal function has been observed to inversely correlate with clinical outcome in other cardiomyopathies, its prognostic significance in patients with left ventricular non-compaction cardiomyopathy (LVNC) has not been investigated. The aim of this study was to determine the prognostic value of renal function in LVNC patients. METHODS: Patients with isolated LVNC as diagnosed by echocardiography and/or magnetic resonance imaging in 4 Swiss centers were retrospectively analyzed for this study. Values for creatinine, urea, and estimated glomerular filtration rate (eGFR) as assessed by the CKD-EPI 2009 formula were collected and analyzed by a Cox regression model for the occurrence of a composite endpoint (death or heart transplantation). RESULTS: During the median observation period of 7.4 years 23 patients reached the endpoint. The age-and gender-corrected hazard ratios (HR) for death or heart transplantation were: 1.9 (95% confidence interval [CI] 1.4–2.6) for each increase over baseline creatinine level of 30 μmol/L (p < 0.001), 1.6 (95% CI 1.2–2.2) for each increase over baseline urea level of 5 mmol/L (p = 0.004), and 3.6 (95% CI 1.9–6.9) for each decrease below baseline eGFR level of 30 mL/min (p ≤ 0.001). The HR (log2) for every doubling of creatinine was 7.7 (95% CI 3–19.8; p < 0.001), for every doubling of urea 2.5 (95% CI 1.5–4.3; p < 0.001), and for every bisection of eGFR 5.3 (95% CI 2.4–11.6; p < 0.001). CONCLUSIONS: This study provides evidence that in patients with LVNC impairment in renal function is associated with an increased risk of death and heart transplantation suggesting that kidney function assessment should be standard in risk assessment of LVNC patients. Via Medica 2023-10-27 /pmc/articles/PMC10635721/ /pubmed/36385602 http://dx.doi.org/10.5603/CJ.a2022.0105 Text en Copyright © 2023 Via Medica https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially
spellingShingle Clinical Cardiology
Erhart, Ladina
Kaufmann, Beat A.
Gencer, Baris
Haager, Philipp K.
Müller, Hajo
Kobza, Richard
Held, Leonhard
Stämpfli, Simon F.
Renal dysfunction and outcome in left ventricular non-compaction
title Renal dysfunction and outcome in left ventricular non-compaction
title_full Renal dysfunction and outcome in left ventricular non-compaction
title_fullStr Renal dysfunction and outcome in left ventricular non-compaction
title_full_unstemmed Renal dysfunction and outcome in left ventricular non-compaction
title_short Renal dysfunction and outcome in left ventricular non-compaction
title_sort renal dysfunction and outcome in left ventricular non-compaction
topic Clinical Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635721/
https://www.ncbi.nlm.nih.gov/pubmed/36385602
http://dx.doi.org/10.5603/CJ.a2022.0105
work_keys_str_mv AT erhartladina renaldysfunctionandoutcomeinleftventricularnoncompaction
AT kaufmannbeata renaldysfunctionandoutcomeinleftventricularnoncompaction
AT gencerbaris renaldysfunctionandoutcomeinleftventricularnoncompaction
AT haagerphilippk renaldysfunctionandoutcomeinleftventricularnoncompaction
AT mullerhajo renaldysfunctionandoutcomeinleftventricularnoncompaction
AT kobzarichard renaldysfunctionandoutcomeinleftventricularnoncompaction
AT heldleonhard renaldysfunctionandoutcomeinleftventricularnoncompaction
AT stampflisimonf renaldysfunctionandoutcomeinleftventricularnoncompaction