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Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma
Glioblastoma are known for its aggressive intracranial course of disease, where the overall survival is less than 18 months. Of late, the World Health Organization has reclassified and renamed secondary glioblastomas as isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas, which is relatively...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635773/ https://www.ncbi.nlm.nih.gov/pubmed/37969678 http://dx.doi.org/10.1055/s-0042-1757425 |
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author | Thimma Sudarsan, Rishan Ramanujan, Vishnu Rajendran, Adhithyan Shafi, Sadiya Patil, Sushma Ghosh, Siddhartha Jalali, Rakesh |
author_facet | Thimma Sudarsan, Rishan Ramanujan, Vishnu Rajendran, Adhithyan Shafi, Sadiya Patil, Sushma Ghosh, Siddhartha Jalali, Rakesh |
author_sort | Thimma Sudarsan, Rishan |
collection | PubMed |
description | Glioblastoma are known for its aggressive intracranial course of disease, where the overall survival is less than 18 months. Of late, the World Health Organization has reclassified and renamed secondary glioblastomas as isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas, which is relatively better than its IDH wild-type counterpart; however, overall survival remains poor. In such tumors, metastases outside the craniospinal neuraxis is very rare, and does sometimes present with symptoms which create a diagnostic dilemma and arriving at such diagnosis is still challenging even for the best of the clinicians worldwide. Here we present such a rare case scenario, where a grade 4 astrocytoma that has transformed from a low-grade glioma, presenting with bone metastases, its workup, treatment, and various possible mechanisms underlying such a rare event, and the need of such clinical scenario especially long-term survivors to be wary of distant metastases. |
format | Online Article Text |
id | pubmed-10635773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106357732023-11-15 Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma Thimma Sudarsan, Rishan Ramanujan, Vishnu Rajendran, Adhithyan Shafi, Sadiya Patil, Sushma Ghosh, Siddhartha Jalali, Rakesh South Asian J Cancer Glioblastoma are known for its aggressive intracranial course of disease, where the overall survival is less than 18 months. Of late, the World Health Organization has reclassified and renamed secondary glioblastomas as isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas, which is relatively better than its IDH wild-type counterpart; however, overall survival remains poor. In such tumors, metastases outside the craniospinal neuraxis is very rare, and does sometimes present with symptoms which create a diagnostic dilemma and arriving at such diagnosis is still challenging even for the best of the clinicians worldwide. Here we present such a rare case scenario, where a grade 4 astrocytoma that has transformed from a low-grade glioma, presenting with bone metastases, its workup, treatment, and various possible mechanisms underlying such a rare event, and the need of such clinical scenario especially long-term survivors to be wary of distant metastases. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-12-31 /pmc/articles/PMC10635773/ /pubmed/37969678 http://dx.doi.org/10.1055/s-0042-1757425 Text en MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Thimma Sudarsan, Rishan Ramanujan, Vishnu Rajendran, Adhithyan Shafi, Sadiya Patil, Sushma Ghosh, Siddhartha Jalali, Rakesh Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma |
title | Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma |
title_full | Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma |
title_fullStr | Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma |
title_full_unstemmed | Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma |
title_short | Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma |
title_sort | rare case of extracranial metastases in a patient with idh-mutant glioblastoma |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635773/ https://www.ncbi.nlm.nih.gov/pubmed/37969678 http://dx.doi.org/10.1055/s-0042-1757425 |
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