Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects

TRPM7, a TRP channel with ion conductance and kinase activities, has emerged as an attractive drug target for immunomodulation. Reverse genetics and cell biological studies have already established a key role for TRPM7 in the inflammatory activation of macrophages. Advancing TRPM7 as a viable molecu...

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Detalles Bibliográficos
Autores principales: Busey, Gregory W., Manjegowda, Mohan C., Huang, Tao, Iobst, Wesley H., Naphade, Shardul S., Kennedy, Joel A., Doyle, Catherine A., Seegren, Philip V., Lynch, Kevin R., Desai, Bimal N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635799/
https://www.ncbi.nlm.nih.gov/pubmed/37943249
http://dx.doi.org/10.1085/jgp.202313419

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