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Long-term Effect of Smoking on Serum Pepsinogen Values

Background: The serum pepsinogen I to II ratio (PG I/II) is related to the risk of stomach cancer. Smoking is an established risk factor for stomach cancer. The effect of smoking on the change in PG I/II over a 7-year span was investigated. Methods: Data were from 1889 male subjects who underwent ph...

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Autores principales: Kikuchi, Shogo, Kurosawa, Michiko, Sakiyama, Tsuguo, Tenjin, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635803/
https://www.ncbi.nlm.nih.gov/pubmed/12395878
http://dx.doi.org/10.2188/jea.12.351
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author Kikuchi, Shogo
Kurosawa, Michiko
Sakiyama, Tsuguo
Tenjin, Hiroshi
author_facet Kikuchi, Shogo
Kurosawa, Michiko
Sakiyama, Tsuguo
Tenjin, Hiroshi
author_sort Kikuchi, Shogo
collection PubMed
description Background: The serum pepsinogen I to II ratio (PG I/II) is related to the risk of stomach cancer. Smoking is an established risk factor for stomach cancer. The effect of smoking on the change in PG I/II over a 7-year span was investigated. Methods: Data were from 1889 male subjects who underwent phlebotomy in both 1989 and 1996. The subjects were classified into smoking and non-smoking groups: those who continued smoking, and those who never smoked during the span. The subjects were stratified by Helicobacter pylori status (negative or positive) and age (20-29 or 30-56 years in 1989), and the change in PG I/II was compared between the smoking and the non-smoking groups. Results: PG I/II increased less (age adjusted mean ±standard error of the difference was 0.209±0.069, p<0.001) and less frequently in the smoking group (65.8% versus 58.9%, p=0.002), but these differences were not clear among H. pylori-positive subjects. Conclusions: The less frequent increase (i.e. a more frequent decline) in PG I/II may be a long-term effect of smoking, although the effect is not clear under H. pylori infection. The decline may be one of the mechanisms through which smoking elevates the risk of stomach cancer.
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spelling pubmed-106358032023-11-15 Long-term Effect of Smoking on Serum Pepsinogen Values Kikuchi, Shogo Kurosawa, Michiko Sakiyama, Tsuguo Tenjin, Hiroshi J Epidemiol Original Article Background: The serum pepsinogen I to II ratio (PG I/II) is related to the risk of stomach cancer. Smoking is an established risk factor for stomach cancer. The effect of smoking on the change in PG I/II over a 7-year span was investigated. Methods: Data were from 1889 male subjects who underwent phlebotomy in both 1989 and 1996. The subjects were classified into smoking and non-smoking groups: those who continued smoking, and those who never smoked during the span. The subjects were stratified by Helicobacter pylori status (negative or positive) and age (20-29 or 30-56 years in 1989), and the change in PG I/II was compared between the smoking and the non-smoking groups. Results: PG I/II increased less (age adjusted mean ±standard error of the difference was 0.209±0.069, p<0.001) and less frequently in the smoking group (65.8% versus 58.9%, p=0.002), but these differences were not clear among H. pylori-positive subjects. Conclusions: The less frequent increase (i.e. a more frequent decline) in PG I/II may be a long-term effect of smoking, although the effect is not clear under H. pylori infection. The decline may be one of the mechanisms through which smoking elevates the risk of stomach cancer. Japan Epidemiological Association 2007-11-30 /pmc/articles/PMC10635803/ /pubmed/12395878 http://dx.doi.org/10.2188/jea.12.351 Text en © 2002 Japan Epidemiological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Kikuchi, Shogo
Kurosawa, Michiko
Sakiyama, Tsuguo
Tenjin, Hiroshi
Long-term Effect of Smoking on Serum Pepsinogen Values
title Long-term Effect of Smoking on Serum Pepsinogen Values
title_full Long-term Effect of Smoking on Serum Pepsinogen Values
title_fullStr Long-term Effect of Smoking on Serum Pepsinogen Values
title_full_unstemmed Long-term Effect of Smoking on Serum Pepsinogen Values
title_short Long-term Effect of Smoking on Serum Pepsinogen Values
title_sort long-term effect of smoking on serum pepsinogen values
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635803/
https://www.ncbi.nlm.nih.gov/pubmed/12395878
http://dx.doi.org/10.2188/jea.12.351
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