Deconvolution of clinical variance in CAR-T cell pharmacology and response

Chimeric antigen receptor T cell (CAR-T) expansion and persistence vary widely among patients and predict both efficacy and toxicity. However, the mechanisms underlying clinical outcomes and patient variability are poorly defined. In this study, we developed a mathematical description of T cell resp...

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Detalles Bibliográficos
Autores principales: Kirouac, Daniel C., Zmurchok, Cole, Deyati, Avisek, Sicherman, Jordan, Bond, Chris, Zandstra, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635825/
https://www.ncbi.nlm.nih.gov/pubmed/36849828
http://dx.doi.org/10.1038/s41587-023-01687-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635825/
https://www.ncbi.nlm.nih.gov/pubmed/36849828
http://dx.doi.org/10.1038/s41587-023-01687-x

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