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Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation. Aberrant activity of NLRP3 occurs in many human diseases. NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum. Higher resolution imaging of this signaling platform is needed to unde...

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Detalles Bibliográficos
Autores principales:	Liu, Yangci, Zhai, Haoming, Alemayehu, Helen, Boulanger, Jérôme, Hopkins, Lee J., Borgeaud, Alicia C., Heroven, Christina, Howe, Jonathan D., Leigh, Kendra E., Bryant, Clare E., Modis, Yorgo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636019/ https://www.ncbi.nlm.nih.gov/pubmed/37945612 http://dx.doi.org/10.1038/s41467-023-43180-8

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