Cargando…

Ultrastructure of noise-induced cochlear synaptopathy

Acoustic overexposure can eliminate synapses between inner hair cells (IHCs) and auditory nerve fibers (ANFs), even if hair-cell function recovers. This synaptopathy has been extensively studied by confocal microscopy, however, understanding the nature and sequence of damage requires ultrastructural...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moverman, Daniel J., Liberman, Leslie D., Kraemer, Stephan, Corfas, Gabriel, Liberman, M. Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636047/ https://www.ncbi.nlm.nih.gov/pubmed/37945811 http://dx.doi.org/10.1038/s41598-023-46859-6

Ejemplares similares

Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3
por: Hashimoto, Ken, et al.
Publicado: (2019)

Blast-induced cochlear synaptopathy in chinchillas
por: Hickman, T. T., et al.
Publicado: (2018)

Cochlear Neurotrophin‐3 overexpression at mid‐life prevents age‐related inner hair cell synaptopathy and slows age‐related hearing loss
por: Cassinotti, Luis R., et al.
Publicado: (2022)

Cochlear Synaptopathy Changes Sound-Evoked Activity Without Changing Spontaneous Discharge in the Mouse Inferior Colliculus
por: Shaheen, Luke A., et al.
Publicado: (2018)

Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure
por: Suzuki, Jun, et al.
Publicado: (2016)

Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
por: Shi, Lijuan, et al.
Publicado: (2016)

Cochlear Synaptic Degeneration and Regeneration After Noise: Effects of Age and Neuronal Subgroup
por: Hickman, Tyler T., et al.
Publicado: (2021)

Effects of Age and Noise Exposure on Proxy Measures of Cochlear Synaptopathy
por: Prendergast, Garreth, et al.
Publicado: (2019)

Type II Cochlear Ganglion Neurons Do Not Drive the Olivocochlear Reflex: Re-Examination of the Cochlear Phenotype in Peripherin Knock-Out Mice
por: Maison, Stéphane, et al.
Publicado: (2016)

Chronic Conductive Hearing Loss Leads to Cochlear Degeneration
por: Liberman, M. Charles, et al.
Publicado: (2015)

Preventive Effects of Ginkgo-Extract EGb 761(®) on Noise Trauma-Induced Cochlear Synaptopathy
por: Tziridis, Konstantin, et al.
Publicado: (2022)

Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy
por: Guest, Hannah, et al.
Publicado: (2017)

Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
por: Guest, Hannah, et al.
Publicado: (2018)

Integrated stress response inhibition provides sex-dependent protection against noise-induced cochlear synaptopathy
por: Rouse, Stephanie L., et al.
Publicado: (2020)

Binaural Processing Deficits Due to Synaptopathy and Myelin Defects
por: Budak, Maral, et al.
Publicado: (2022)

Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Pubescent Mice
por: Jensen, Jane Bjerg, et al.
Publicado: (2015)

Auditory synaptopathy, auditory neuropathy, and cochlear implantation
por: Shearer, Aiden Eliot, et al.
Publicado: (2019)

Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice
por: Wan, Guoqiang, et al.
Publicado: (2019)

Synaptic migration and reorganization after noise exposure suggests regeneration in a mature mammalian cochlea
por: Hickman, Tyler T., et al.
Publicado: (2020)

Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects
por: Budak, Maral, et al.
Publicado: (2021)

Auditory Brainstem Response to Paired Click Stimulation as an Indicator of Peripheral Synaptic Health in Noise-Induced Cochlear Synaptopathy
por: Lee, Jae-Hun, et al.
Publicado: (2021)

Reliability and interrelations of seven proxy measures of cochlear synaptopathy
por: Guest, Hannah, et al.
Publicado: (2019)

Weak Middle-Ear-Muscle Reflex in Humans with Noise-Induced Tinnitus and Normal Hearing May Reflect Cochlear Synaptopathy
por: Wojtczak, Magdalena, et al.
Publicado: (2017)

Effects of age on electrophysiological measures of cochlear synaptopathy in humans
por: Carcagno, Samuele, et al.
Publicado: (2020)

Categorization of tinnitus listeners with a focus on cochlear synaptopathy
por: Casolani, Chiara, et al.
Publicado: (2022)

Correction: Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects
por: Budak, Maral, et al.
Publicado: (2021)

Noise-induced and age-related hearing loss: new perspectives and potential therapies
por: Liberman, M Charles
Publicado: (2017)

Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis
por: Chen, Feifan, et al.
Publicado: (2021)

Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
por: Wan, Guoqiang, et al.
Publicado: (2014)

Cochlear Synaptopathy Causes Loudness Perception Impairment without Hearing Loss
por: Çildir, Bünyamin, et al.
Publicado: (2022)

Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response
por: Bao, Jianxin, et al.
Publicado: (2022)

Cochlear Synaptopathy: A Primary Factor Affecting Speech Recognition Performance in Presbycusis
por: Chen, Zhe, et al.
Publicado: (2021)

Metabotropic glutamate receptor: A new possible therapeutic target for cochlear synaptopathy
por: Mahdi, Parvane, et al.
Publicado: (2022)

Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction
por: Suzuki, Jun, et al.
Publicado: (2017)

Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
por: Badash, Ido, et al.
Publicado: (2021)

Assessment of cochlear synaptopathy by electrocochleography to low frequencies in a preclinical model and human subjects
por: Haggerty, Raymond A., et al.
Publicado: (2023)

AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy
por: Chen, Hengchao, et al.
Publicado: (2018)

Prolonged Exposure of CBA/Ca Mice to Moderately Loud Noise Can Cause Cochlear Synaptopathy but Not Tinnitus or Hyperacusis as Assessed With the Acoustic Startle Reflex
por: Pienkowski, Martin
Publicado: (2018)

Corrigendum: Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction
por: Suzuki, Jun, et al.
Publicado: (2017)

Animal-to-Human Translation Difficulties and Problems With Proposed Coding-in-Noise Deficits in Noise-Induced Synaptopathy and Hidden Hearing Loss
por: Ripley, Sara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h1q94q8tjfh3lhjgt8q5ehqt85