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TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 but can occasionally become abortive generating permanent protein-linked single strand breaks (SSBs). The repair of these breaks is initiated by tyrosyl-DNA phosphodiesterase 1 (...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636166/ https://www.ncbi.nlm.nih.gov/pubmed/37945566 http://dx.doi.org/10.1038/s41467-023-42622-7 |