A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation

Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In this study, we developed a tyrosine kinase inhibitor 1D228, which exhibited excellent anti-tumor activity by targeting c-Met and TRK. Models in vitro, 1D228 showed a...

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Detalles Bibliográficos
Autores principales: An, Baijiao, Nie, Wenyan, Hu, Jinhui, Fan, Yangyang, Nie, Haoran, Wang, Mengxuan, Zhao, Yaxuan, Yao, Han, Ren, Yuanyuan, Zhang, Chuanchuan, Wei, Mengna, Li, Wei, Liu, Jiadai, Yang, Chunhua, Zhang, Yin, Li, Xingshu, Tian, Geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636171/
https://www.ncbi.nlm.nih.gov/pubmed/37945598
http://dx.doi.org/10.1038/s41419-023-06246-5

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