Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model

Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC) synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying regulatory mechanisms remain unknown. Here, we elucidated an epigenetic pathway driven by microRNA regulation of β-EP synthesis in ARC ne...

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Detalles Bibliográficos
Autores principales: Tao, Yu, Zhang, Yuan, Jin, Xiaohong, Hua, Nan, Liu, Hong, Qi, Renfei, Huang, Zitong, Sun, Yufang, Jiang, Dongsheng, Snutch, Terrance P., Jiang, Xinghong, Tao, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636187/
https://www.ncbi.nlm.nih.gov/pubmed/37945654
http://dx.doi.org/10.1038/s41467-023-43022-7

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