Cargando…

Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning

The auditory striatum, a sensory portion of the dorsal striatum, plays an essential role in learning and memory. In contrast to its roles and underlying mechanisms in operant conditioning, however, little is known about its contribution to classical auditory fear conditioning. Here, we reveal the fu...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Allen P. F., Chen, Lu, Shi, Kaiyo W., Cheng, Eileen, Ge, Shaoyu, Xiong, Qiaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636191/
https://www.ncbi.nlm.nih.gov/pubmed/37945595
http://dx.doi.org/10.1038/s41467-023-43066-9
_version_ 1785133161166929920
author Chen, Allen P. F.
Chen, Lu
Shi, Kaiyo W.
Cheng, Eileen
Ge, Shaoyu
Xiong, Qiaojie
author_facet Chen, Allen P. F.
Chen, Lu
Shi, Kaiyo W.
Cheng, Eileen
Ge, Shaoyu
Xiong, Qiaojie
author_sort Chen, Allen P. F.
collection PubMed
description The auditory striatum, a sensory portion of the dorsal striatum, plays an essential role in learning and memory. In contrast to its roles and underlying mechanisms in operant conditioning, however, little is known about its contribution to classical auditory fear conditioning. Here, we reveal the function of the auditory striatum in auditory-conditioned fear memory. We find that optogenetically inhibiting auditory striatal neurons impairs fear memory formation, which is mediated through the striatal-amygdala pathway. Using calcium imaging in behaving mice, we find that auditory striatal neuronal responses to conditioned tones potentiate across memory acquisition and expression. Furthermore, nigrostriatal dopaminergic projections plays an important role in modulating conditioning-induced striatal potentiation. Together, these findings demonstrate the existence of a nigro-striatal-amygdala circuit for conditioned fear memory formation and expression.
format Online
Article
Text
id pubmed-10636191
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-106361912023-11-11 Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning Chen, Allen P. F. Chen, Lu Shi, Kaiyo W. Cheng, Eileen Ge, Shaoyu Xiong, Qiaojie Nat Commun Article The auditory striatum, a sensory portion of the dorsal striatum, plays an essential role in learning and memory. In contrast to its roles and underlying mechanisms in operant conditioning, however, little is known about its contribution to classical auditory fear conditioning. Here, we reveal the function of the auditory striatum in auditory-conditioned fear memory. We find that optogenetically inhibiting auditory striatal neurons impairs fear memory formation, which is mediated through the striatal-amygdala pathway. Using calcium imaging in behaving mice, we find that auditory striatal neuronal responses to conditioned tones potentiate across memory acquisition and expression. Furthermore, nigrostriatal dopaminergic projections plays an important role in modulating conditioning-induced striatal potentiation. Together, these findings demonstrate the existence of a nigro-striatal-amygdala circuit for conditioned fear memory formation and expression. Nature Publishing Group UK 2023-11-09 /pmc/articles/PMC10636191/ /pubmed/37945595 http://dx.doi.org/10.1038/s41467-023-43066-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chen, Allen P. F.
Chen, Lu
Shi, Kaiyo W.
Cheng, Eileen
Ge, Shaoyu
Xiong, Qiaojie
Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
title Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
title_full Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
title_fullStr Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
title_full_unstemmed Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
title_short Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
title_sort nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636191/
https://www.ncbi.nlm.nih.gov/pubmed/37945595
http://dx.doi.org/10.1038/s41467-023-43066-9
work_keys_str_mv AT chenallenpf nigrostriataldopaminemodulatesthestriatalamygdalapathwayinauditoryfearconditioning
AT chenlu nigrostriataldopaminemodulatesthestriatalamygdalapathwayinauditoryfearconditioning
AT shikaiyow nigrostriataldopaminemodulatesthestriatalamygdalapathwayinauditoryfearconditioning
AT chengeileen nigrostriataldopaminemodulatesthestriatalamygdalapathwayinauditoryfearconditioning
AT geshaoyu nigrostriataldopaminemodulatesthestriatalamygdalapathwayinauditoryfearconditioning
AT xiongqiaojie nigrostriataldopaminemodulatesthestriatalamygdalapathwayinauditoryfearconditioning