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Genome-wide interaction analysis of folate for colorectal cancer risk

BACKGROUND: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate met...

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Autores principales: Bouras, Emmanouil, Kim, Andre E., Lin, Yi, Morrison, John, Du, Mengmeng, Albanes, Demetrius, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bien, Stephanie A., Bishop, Timothy D., Brenner, Hermann, Budiarto, Arif, Burnett-Hartman, Andrea, Campbell, Peter T., Carreras-Torres, Robert, Casey, Graham, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Conti, David V., Cotterchio, Michelle, Devall, Matthew, Diez-Obrero, Virginia, Dimou, Niki, Drew, David A., Figueiredo, Jane C., Giles, Graham G., Gruber, Stephen B., Gunter, Marc J., Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Joshi, Amit D., Kawaguchi, Eric S., Keku, Temitope O., Kundaje, Anshul, Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Lynch, Brigid M., Mahesworo, Bharuno, Männistö, Satu, Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Obón-Santacana, Mireia, Ose, Jennifer, Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Pellatt, Andrew J., Peoples, Anita R., Platz, Elizabeth A., Potter, John D., Qi, Lihong, Qu, Conghui, Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori C., Schmit, Stephanie L., Shcherbina, Anna, Stern, Mariana C., Su, Yu-Ru, Tangen, Catherine M., Thomas, Duncan C., Tian, Yu, Um, Caroline Y., van Duijnhoven, Franzel JB., Van Guelpen, Bethany, Visvanathan, Kala, Wang, Jun, White, Emily, Wolk, Alicja, Woods, Michael O., Ulrich, Cornelia M., Hsu, Li, Gauderman, W James, Peters, Ulrike, Tsilidis, Konstantinos K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Nutrition 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636229/
https://www.ncbi.nlm.nih.gov/pubmed/37640106
http://dx.doi.org/10.1016/j.ajcnut.2023.08.010
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author Bouras, Emmanouil
Kim, Andre E.
Lin, Yi
Morrison, John
Du, Mengmeng
Albanes, Demetrius
Barry, Elizabeth L.
Baurley, James W.
Berndt, Sonja I.
Bien, Stephanie A.
Bishop, Timothy D.
Brenner, Hermann
Budiarto, Arif
Burnett-Hartman, Andrea
Campbell, Peter T.
Carreras-Torres, Robert
Casey, Graham
Cenggoro, Tjeng Wawan
Chan, Andrew T.
Chang-Claude, Jenny
Conti, David V.
Cotterchio, Michelle
Devall, Matthew
Diez-Obrero, Virginia
Dimou, Niki
Drew, David A.
Figueiredo, Jane C.
Giles, Graham G.
Gruber, Stephen B.
Gunter, Marc J.
Harrison, Tabitha A.
Hidaka, Akihisa
Hoffmeister, Michael
Huyghe, Jeroen R.
Joshi, Amit D.
Kawaguchi, Eric S.
Keku, Temitope O.
Kundaje, Anshul
Le Marchand, Loic
Lewinger, Juan Pablo
Li, Li
Lynch, Brigid M.
Mahesworo, Bharuno
Männistö, Satu
Moreno, Victor
Murphy, Neil
Newcomb, Polly A.
Obón-Santacana, Mireia
Ose, Jennifer
Palmer, Julie R.
Papadimitriou, Nikos
Pardamean, Bens
Pellatt, Andrew J.
Peoples, Anita R.
Platz, Elizabeth A.
Potter, John D.
Qi, Lihong
Qu, Conghui
Rennert, Gad
Ruiz-Narvaez, Edward
Sakoda, Lori C.
Schmit, Stephanie L.
Shcherbina, Anna
Stern, Mariana C.
Su, Yu-Ru
Tangen, Catherine M.
Thomas, Duncan C.
Tian, Yu
Um, Caroline Y.
van Duijnhoven, Franzel JB.
Van Guelpen, Bethany
Visvanathan, Kala
Wang, Jun
White, Emily
Wolk, Alicja
Woods, Michael O.
Ulrich, Cornelia M.
Hsu, Li
Gauderman, W James
Peters, Ulrike
Tsilidis, Konstantinos K.
author_facet Bouras, Emmanouil
Kim, Andre E.
Lin, Yi
Morrison, John
Du, Mengmeng
Albanes, Demetrius
Barry, Elizabeth L.
Baurley, James W.
Berndt, Sonja I.
Bien, Stephanie A.
Bishop, Timothy D.
Brenner, Hermann
Budiarto, Arif
Burnett-Hartman, Andrea
Campbell, Peter T.
Carreras-Torres, Robert
Casey, Graham
Cenggoro, Tjeng Wawan
Chan, Andrew T.
Chang-Claude, Jenny
Conti, David V.
Cotterchio, Michelle
Devall, Matthew
Diez-Obrero, Virginia
Dimou, Niki
Drew, David A.
Figueiredo, Jane C.
Giles, Graham G.
Gruber, Stephen B.
Gunter, Marc J.
Harrison, Tabitha A.
Hidaka, Akihisa
Hoffmeister, Michael
Huyghe, Jeroen R.
Joshi, Amit D.
Kawaguchi, Eric S.
Keku, Temitope O.
Kundaje, Anshul
Le Marchand, Loic
Lewinger, Juan Pablo
Li, Li
Lynch, Brigid M.
Mahesworo, Bharuno
Männistö, Satu
Moreno, Victor
Murphy, Neil
Newcomb, Polly A.
Obón-Santacana, Mireia
Ose, Jennifer
Palmer, Julie R.
Papadimitriou, Nikos
Pardamean, Bens
Pellatt, Andrew J.
Peoples, Anita R.
Platz, Elizabeth A.
Potter, John D.
Qi, Lihong
Qu, Conghui
Rennert, Gad
Ruiz-Narvaez, Edward
Sakoda, Lori C.
Schmit, Stephanie L.
Shcherbina, Anna
Stern, Mariana C.
Su, Yu-Ru
Tangen, Catherine M.
Thomas, Duncan C.
Tian, Yu
Um, Caroline Y.
van Duijnhoven, Franzel JB.
Van Guelpen, Bethany
Visvanathan, Kala
Wang, Jun
White, Emily
Wolk, Alicja
Woods, Michael O.
Ulrich, Cornelia M.
Hsu, Li
Gauderman, W James
Peters, Ulrike
Tsilidis, Konstantinos K.
author_sort Bouras, Emmanouil
collection PubMed
description BACKGROUND: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate’s role in CRC. OBJECTIVES: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk. METHODS: We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO). RESULTS: Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10(-8)) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10(-8)). No interactions were observed for dietary and total folate. CONCLUSIONS: Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding.
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spelling pubmed-106362292023-11-15 Genome-wide interaction analysis of folate for colorectal cancer risk Bouras, Emmanouil Kim, Andre E. Lin, Yi Morrison, John Du, Mengmeng Albanes, Demetrius Barry, Elizabeth L. Baurley, James W. Berndt, Sonja I. Bien, Stephanie A. Bishop, Timothy D. Brenner, Hermann Budiarto, Arif Burnett-Hartman, Andrea Campbell, Peter T. Carreras-Torres, Robert Casey, Graham Cenggoro, Tjeng Wawan Chan, Andrew T. Chang-Claude, Jenny Conti, David V. Cotterchio, Michelle Devall, Matthew Diez-Obrero, Virginia Dimou, Niki Drew, David A. Figueiredo, Jane C. Giles, Graham G. Gruber, Stephen B. Gunter, Marc J. Harrison, Tabitha A. Hidaka, Akihisa Hoffmeister, Michael Huyghe, Jeroen R. Joshi, Amit D. Kawaguchi, Eric S. Keku, Temitope O. Kundaje, Anshul Le Marchand, Loic Lewinger, Juan Pablo Li, Li Lynch, Brigid M. Mahesworo, Bharuno Männistö, Satu Moreno, Victor Murphy, Neil Newcomb, Polly A. Obón-Santacana, Mireia Ose, Jennifer Palmer, Julie R. Papadimitriou, Nikos Pardamean, Bens Pellatt, Andrew J. Peoples, Anita R. Platz, Elizabeth A. Potter, John D. Qi, Lihong Qu, Conghui Rennert, Gad Ruiz-Narvaez, Edward Sakoda, Lori C. Schmit, Stephanie L. Shcherbina, Anna Stern, Mariana C. Su, Yu-Ru Tangen, Catherine M. Thomas, Duncan C. Tian, Yu Um, Caroline Y. van Duijnhoven, Franzel JB. Van Guelpen, Bethany Visvanathan, Kala Wang, Jun White, Emily Wolk, Alicja Woods, Michael O. Ulrich, Cornelia M. Hsu, Li Gauderman, W James Peters, Ulrike Tsilidis, Konstantinos K. Am J Clin Nutr Original Research Article BACKGROUND: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate’s role in CRC. OBJECTIVES: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk. METHODS: We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO). RESULTS: Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10(-8)) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10(-8)). No interactions were observed for dietary and total folate. CONCLUSIONS: Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding. American Society for Nutrition 2023-11 2023-08-26 /pmc/articles/PMC10636229/ /pubmed/37640106 http://dx.doi.org/10.1016/j.ajcnut.2023.08.010 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research Article
Bouras, Emmanouil
Kim, Andre E.
Lin, Yi
Morrison, John
Du, Mengmeng
Albanes, Demetrius
Barry, Elizabeth L.
Baurley, James W.
Berndt, Sonja I.
Bien, Stephanie A.
Bishop, Timothy D.
Brenner, Hermann
Budiarto, Arif
Burnett-Hartman, Andrea
Campbell, Peter T.
Carreras-Torres, Robert
Casey, Graham
Cenggoro, Tjeng Wawan
Chan, Andrew T.
Chang-Claude, Jenny
Conti, David V.
Cotterchio, Michelle
Devall, Matthew
Diez-Obrero, Virginia
Dimou, Niki
Drew, David A.
Figueiredo, Jane C.
Giles, Graham G.
Gruber, Stephen B.
Gunter, Marc J.
Harrison, Tabitha A.
Hidaka, Akihisa
Hoffmeister, Michael
Huyghe, Jeroen R.
Joshi, Amit D.
Kawaguchi, Eric S.
Keku, Temitope O.
Kundaje, Anshul
Le Marchand, Loic
Lewinger, Juan Pablo
Li, Li
Lynch, Brigid M.
Mahesworo, Bharuno
Männistö, Satu
Moreno, Victor
Murphy, Neil
Newcomb, Polly A.
Obón-Santacana, Mireia
Ose, Jennifer
Palmer, Julie R.
Papadimitriou, Nikos
Pardamean, Bens
Pellatt, Andrew J.
Peoples, Anita R.
Platz, Elizabeth A.
Potter, John D.
Qi, Lihong
Qu, Conghui
Rennert, Gad
Ruiz-Narvaez, Edward
Sakoda, Lori C.
Schmit, Stephanie L.
Shcherbina, Anna
Stern, Mariana C.
Su, Yu-Ru
Tangen, Catherine M.
Thomas, Duncan C.
Tian, Yu
Um, Caroline Y.
van Duijnhoven, Franzel JB.
Van Guelpen, Bethany
Visvanathan, Kala
Wang, Jun
White, Emily
Wolk, Alicja
Woods, Michael O.
Ulrich, Cornelia M.
Hsu, Li
Gauderman, W James
Peters, Ulrike
Tsilidis, Konstantinos K.
Genome-wide interaction analysis of folate for colorectal cancer risk
title Genome-wide interaction analysis of folate for colorectal cancer risk
title_full Genome-wide interaction analysis of folate for colorectal cancer risk
title_fullStr Genome-wide interaction analysis of folate for colorectal cancer risk
title_full_unstemmed Genome-wide interaction analysis of folate for colorectal cancer risk
title_short Genome-wide interaction analysis of folate for colorectal cancer risk
title_sort genome-wide interaction analysis of folate for colorectal cancer risk
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636229/
https://www.ncbi.nlm.nih.gov/pubmed/37640106
http://dx.doi.org/10.1016/j.ajcnut.2023.08.010
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