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Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction

BACKGROUND: Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modul...

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Autores principales: Wang, Yang, Qin, Yun, Li, Hui, Yao, Dezhong, Sun, Bo, Gong, Jinnan, Dai, Yu, Wen, Chao, Zhang, Lingrui, Zhang, Chenchen, Luo, Cheng, Zhu, Tianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636388/
https://www.ncbi.nlm.nih.gov/pubmed/37721727
http://dx.doi.org/10.1002/brb3.3241
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author Wang, Yang
Qin, Yun
Li, Hui
Yao, Dezhong
Sun, Bo
Gong, Jinnan
Dai, Yu
Wen, Chao
Zhang, Lingrui
Zhang, Chenchen
Luo, Cheng
Zhu, Tianmin
author_facet Wang, Yang
Qin, Yun
Li, Hui
Yao, Dezhong
Sun, Bo
Gong, Jinnan
Dai, Yu
Wen, Chao
Zhang, Lingrui
Zhang, Chenchen
Luo, Cheng
Zhu, Tianmin
author_sort Wang, Yang
collection PubMed
description BACKGROUND: Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA. METHODS: Thirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group. RESULTS: In comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex. CONCLUSION: These findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA.
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spelling pubmed-106363882023-11-15 Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction Wang, Yang Qin, Yun Li, Hui Yao, Dezhong Sun, Bo Gong, Jinnan Dai, Yu Wen, Chao Zhang, Lingrui Zhang, Chenchen Luo, Cheng Zhu, Tianmin Brain Behav Original Articles BACKGROUND: Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA. METHODS: Thirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group. RESULTS: In comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex. CONCLUSION: These findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA. John Wiley and Sons Inc. 2023-09-18 /pmc/articles/PMC10636388/ /pubmed/37721727 http://dx.doi.org/10.1002/brb3.3241 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wang, Yang
Qin, Yun
Li, Hui
Yao, Dezhong
Sun, Bo
Gong, Jinnan
Dai, Yu
Wen, Chao
Zhang, Lingrui
Zhang, Chenchen
Luo, Cheng
Zhu, Tianmin
Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
title Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
title_full Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
title_fullStr Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
title_full_unstemmed Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
title_short Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
title_sort acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636388/
https://www.ncbi.nlm.nih.gov/pubmed/37721727
http://dx.doi.org/10.1002/brb3.3241
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