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Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
BACKGROUND: Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modul...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636388/ https://www.ncbi.nlm.nih.gov/pubmed/37721727 http://dx.doi.org/10.1002/brb3.3241 |
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author | Wang, Yang Qin, Yun Li, Hui Yao, Dezhong Sun, Bo Gong, Jinnan Dai, Yu Wen, Chao Zhang, Lingrui Zhang, Chenchen Luo, Cheng Zhu, Tianmin |
author_facet | Wang, Yang Qin, Yun Li, Hui Yao, Dezhong Sun, Bo Gong, Jinnan Dai, Yu Wen, Chao Zhang, Lingrui Zhang, Chenchen Luo, Cheng Zhu, Tianmin |
author_sort | Wang, Yang |
collection | PubMed |
description | BACKGROUND: Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA. METHODS: Thirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group. RESULTS: In comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex. CONCLUSION: These findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA. |
format | Online Article Text |
id | pubmed-10636388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106363882023-11-15 Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction Wang, Yang Qin, Yun Li, Hui Yao, Dezhong Sun, Bo Gong, Jinnan Dai, Yu Wen, Chao Zhang, Lingrui Zhang, Chenchen Luo, Cheng Zhu, Tianmin Brain Behav Original Articles BACKGROUND: Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA. METHODS: Thirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group. RESULTS: In comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex. CONCLUSION: These findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA. John Wiley and Sons Inc. 2023-09-18 /pmc/articles/PMC10636388/ /pubmed/37721727 http://dx.doi.org/10.1002/brb3.3241 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Wang, Yang Qin, Yun Li, Hui Yao, Dezhong Sun, Bo Gong, Jinnan Dai, Yu Wen, Chao Zhang, Lingrui Zhang, Chenchen Luo, Cheng Zhu, Tianmin Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
title | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
title_full | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
title_fullStr | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
title_full_unstemmed | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
title_short | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
title_sort | acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636388/ https://www.ncbi.nlm.nih.gov/pubmed/37721727 http://dx.doi.org/10.1002/brb3.3241 |
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