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Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review

BACKGROUND AND OBJECTIVE: Current management of chronic cough is largely based on sequential therapeutic trials. The concept of treatable traits was first introduced for individualized treatment of chronic airway diseases; however, it has emerged as a potentially useful strategy in revising the mana...

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Autores principales: Lee, Ji-Ho, Lee, Ji-Hyang, Park, So-Young, Koskela, Heikki Olavi, Song, Woo-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636432/
https://www.ncbi.nlm.nih.gov/pubmed/37969307
http://dx.doi.org/10.21037/jtd-23-135
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author Lee, Ji-Ho
Lee, Ji-Hyang
Park, So-Young
Koskela, Heikki Olavi
Song, Woo-Jung
author_facet Lee, Ji-Ho
Lee, Ji-Hyang
Park, So-Young
Koskela, Heikki Olavi
Song, Woo-Jung
author_sort Lee, Ji-Ho
collection PubMed
description BACKGROUND AND OBJECTIVE: Current management of chronic cough is largely based on sequential therapeutic trials. The concept of treatable traits was first introduced for individualized treatment of chronic airway diseases; however, it has emerged as a potentially useful strategy in revising the management of chronic cough. This narrative review aimed to analyze the literature to determine if fractional exhaled nitric oxide (FeNO) is a treatable trait in chronic cough, compared to other type 2 biomarkers, and to summarize current knowledge and gaps in the clinical application. METHODS: An online electronic search was performed on PubMed, Web of Science, and Scopus of English-language literature with following keywords: cough, nitric oxide (NO), eosinophils, biomarker, and treatable trait. Relevance and eligibility of each article were assessed by one or more of the authors and a narrative review was composed. KEY CONTENT AND FINDINGS: Eosinophilic or type 2 airway inflammation is a major treatable trait in patients with chronic cough. Induced sputum tests are regarded as the gold standard for defining inflammatory phenotype, however, technically demanding and cannot be widely applied in clinical practice. FeNO, a practical biomarker, has emerged as an alternative to induced sputum analyses. Mechanistic and clinical evidence indicated that FeNO had a potential for diagnostic utility and treatment response predictability. CONCLUSIONS: FeNO measurement may help to identify patients with chronic cough that will benefit from corticosteroid treatment. Further studies are warranted to determine the diagnostic roles of FeNO in the management of patients with chronic cough.
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spelling pubmed-106364322023-11-15 Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review Lee, Ji-Ho Lee, Ji-Hyang Park, So-Young Koskela, Heikki Olavi Song, Woo-Jung J Thorac Dis Review Article on Novel Insights into Chronic Cough BACKGROUND AND OBJECTIVE: Current management of chronic cough is largely based on sequential therapeutic trials. The concept of treatable traits was first introduced for individualized treatment of chronic airway diseases; however, it has emerged as a potentially useful strategy in revising the management of chronic cough. This narrative review aimed to analyze the literature to determine if fractional exhaled nitric oxide (FeNO) is a treatable trait in chronic cough, compared to other type 2 biomarkers, and to summarize current knowledge and gaps in the clinical application. METHODS: An online electronic search was performed on PubMed, Web of Science, and Scopus of English-language literature with following keywords: cough, nitric oxide (NO), eosinophils, biomarker, and treatable trait. Relevance and eligibility of each article were assessed by one or more of the authors and a narrative review was composed. KEY CONTENT AND FINDINGS: Eosinophilic or type 2 airway inflammation is a major treatable trait in patients with chronic cough. Induced sputum tests are regarded as the gold standard for defining inflammatory phenotype, however, technically demanding and cannot be widely applied in clinical practice. FeNO, a practical biomarker, has emerged as an alternative to induced sputum analyses. Mechanistic and clinical evidence indicated that FeNO had a potential for diagnostic utility and treatment response predictability. CONCLUSIONS: FeNO measurement may help to identify patients with chronic cough that will benefit from corticosteroid treatment. Further studies are warranted to determine the diagnostic roles of FeNO in the management of patients with chronic cough. AME Publishing Company 2023-10-24 2023-10-31 /pmc/articles/PMC10636432/ /pubmed/37969307 http://dx.doi.org/10.21037/jtd-23-135 Text en 2023 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article on Novel Insights into Chronic Cough
Lee, Ji-Ho
Lee, Ji-Hyang
Park, So-Young
Koskela, Heikki Olavi
Song, Woo-Jung
Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review
title Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review
title_full Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review
title_fullStr Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review
title_full_unstemmed Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review
title_short Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review
title_sort is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review
topic Review Article on Novel Insights into Chronic Cough
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636432/
https://www.ncbi.nlm.nih.gov/pubmed/37969307
http://dx.doi.org/10.21037/jtd-23-135
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