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Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated

Lysophosphatidic acid is composed of lysophosphatidic acid (LPA) molecules with varied chemical forms. The present cross-sectional study was conducted to investigate the associations of various LPA molecules with liver fibrosis. Forty-six patients affected by various types of liver disease who under...

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Autores principales: Tobita, Hiroshi, Sakai, Hiromichi, Yamaguchi, Akane, Notsu, Yoshitomo, Kataoka, Masatoshi, Yazaki, Tomotaka, Nabika, Toru, Ishihara, Shunji, Kobayashi, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636581/
https://www.ncbi.nlm.nih.gov/pubmed/37970549
http://dx.doi.org/10.3164/jcbn.23-58
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author Tobita, Hiroshi
Sakai, Hiromichi
Yamaguchi, Akane
Notsu, Yoshitomo
Kataoka, Masatoshi
Yazaki, Tomotaka
Nabika, Toru
Ishihara, Shunji
Kobayashi, Hironori
author_facet Tobita, Hiroshi
Sakai, Hiromichi
Yamaguchi, Akane
Notsu, Yoshitomo
Kataoka, Masatoshi
Yazaki, Tomotaka
Nabika, Toru
Ishihara, Shunji
Kobayashi, Hironori
author_sort Tobita, Hiroshi
collection PubMed
description Lysophosphatidic acid is composed of lysophosphatidic acid (LPA) molecules with varied chemical forms. The present cross-sectional study was conducted to investigate the associations of various LPA molecules with liver fibrosis. Forty-six patients affected by various types of liver disease who underwent an ultrasound-guided liver biopsy were recruited for this study. Liver fibrosis was evaluated using histological grading, as well as shear wave velocity (Vs) and serum level of type IV collagen 7S (T4c7s). Serum levels of LPA molecules were determined using liquid-chromatography tandem mass-spectrometry (LC-MSMS). Total LPA showed a significant positive association with fibrosis severity evaluated based on histological grading, Vs, and T4c7s used as parameters, following adjustment for other confounding factors, including disease type, age, gender, body mass index, and high-sensitivity C-reactive protein. This association was replicated when 16:0-LPA was substituted for total LPA. In contrast, when 20:4-LPA was substituted for total LPA, no significant association with liver fibrosis was observed. In conclusion, the degree of association varied among the different LPA molecule chemical forms, suggesting different pathophysiological roles of individual LPA molecules, although total LPA concentration was shown to be associated with liver fibrosis.
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spelling pubmed-106365812023-11-15 Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated Tobita, Hiroshi Sakai, Hiromichi Yamaguchi, Akane Notsu, Yoshitomo Kataoka, Masatoshi Yazaki, Tomotaka Nabika, Toru Ishihara, Shunji Kobayashi, Hironori J Clin Biochem Nutr Original Article Lysophosphatidic acid is composed of lysophosphatidic acid (LPA) molecules with varied chemical forms. The present cross-sectional study was conducted to investigate the associations of various LPA molecules with liver fibrosis. Forty-six patients affected by various types of liver disease who underwent an ultrasound-guided liver biopsy were recruited for this study. Liver fibrosis was evaluated using histological grading, as well as shear wave velocity (Vs) and serum level of type IV collagen 7S (T4c7s). Serum levels of LPA molecules were determined using liquid-chromatography tandem mass-spectrometry (LC-MSMS). Total LPA showed a significant positive association with fibrosis severity evaluated based on histological grading, Vs, and T4c7s used as parameters, following adjustment for other confounding factors, including disease type, age, gender, body mass index, and high-sensitivity C-reactive protein. This association was replicated when 16:0-LPA was substituted for total LPA. In contrast, when 20:4-LPA was substituted for total LPA, no significant association with liver fibrosis was observed. In conclusion, the degree of association varied among the different LPA molecule chemical forms, suggesting different pathophysiological roles of individual LPA molecules, although total LPA concentration was shown to be associated with liver fibrosis. the Society for Free Radical Research Japan 2023-11 2023-08-18 /pmc/articles/PMC10636581/ /pubmed/37970549 http://dx.doi.org/10.3164/jcbn.23-58 Text en Copyright © 2023 JCBN https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Tobita, Hiroshi
Sakai, Hiromichi
Yamaguchi, Akane
Notsu, Yoshitomo
Kataoka, Masatoshi
Yazaki, Tomotaka
Nabika, Toru
Ishihara, Shunji
Kobayashi, Hironori
Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
title Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
title_full Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
title_fullStr Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
title_full_unstemmed Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
title_short Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
title_sort association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636581/
https://www.ncbi.nlm.nih.gov/pubmed/37970549
http://dx.doi.org/10.3164/jcbn.23-58
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