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Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation

Long noncoding RNAs (lncRNAs) are expressed in many brain circuits and types of neurons; nevertheless, their functional significance for normal brain functions remains elusive. Here, we study the functions in the central nervous system of Silc1, an lncRNA we have shown previously to be important for...

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Autores principales: Ben-Tov Perry, Rotem, Tsoory, Michael, Tolmasov, Michael, Ulitsky, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636608/
https://www.ncbi.nlm.nih.gov/pubmed/37742186
http://dx.doi.org/10.1016/j.celrep.2023.113168
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author Ben-Tov Perry, Rotem
Tsoory, Michael
Tolmasov, Michael
Ulitsky, Igor
author_facet Ben-Tov Perry, Rotem
Tsoory, Michael
Tolmasov, Michael
Ulitsky, Igor
author_sort Ben-Tov Perry, Rotem
collection PubMed
description Long noncoding RNAs (lncRNAs) are expressed in many brain circuits and types of neurons; nevertheless, their functional significance for normal brain functions remains elusive. Here, we study the functions in the central nervous system of Silc1, an lncRNA we have shown previously to be important for neuronal regeneration in the peripheral nervous system. We found that Silc1 is rapidly and strongly induced in the hippocampus upon exposure to novelty and is required for efficient spatial learning. Silc1 production is important for induction of Sox11 (its cis-regulated target gene) throughout the CA1–CA3 regions and proper expression of key Sox11 target genes. Consistent with its role in neuronal plasticity, Silc1 levels decline during aging and in models of Alzheimer’s disease. Overall, we describe a plasticity pathway in which Silc1 acts as an immediate-early gene to activate Sox11 and induce a neuronal growth-associated transcriptional program important for learning.
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spelling pubmed-106366082023-11-14 Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation Ben-Tov Perry, Rotem Tsoory, Michael Tolmasov, Michael Ulitsky, Igor Cell Rep Article Long noncoding RNAs (lncRNAs) are expressed in many brain circuits and types of neurons; nevertheless, their functional significance for normal brain functions remains elusive. Here, we study the functions in the central nervous system of Silc1, an lncRNA we have shown previously to be important for neuronal regeneration in the peripheral nervous system. We found that Silc1 is rapidly and strongly induced in the hippocampus upon exposure to novelty and is required for efficient spatial learning. Silc1 production is important for induction of Sox11 (its cis-regulated target gene) throughout the CA1–CA3 regions and proper expression of key Sox11 target genes. Consistent with its role in neuronal plasticity, Silc1 levels decline during aging and in models of Alzheimer’s disease. Overall, we describe a plasticity pathway in which Silc1 acts as an immediate-early gene to activate Sox11 and induce a neuronal growth-associated transcriptional program important for learning. Cell Press 2023-09-23 /pmc/articles/PMC10636608/ /pubmed/37742186 http://dx.doi.org/10.1016/j.celrep.2023.113168 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ben-Tov Perry, Rotem
Tsoory, Michael
Tolmasov, Michael
Ulitsky, Igor
Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation
title Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation
title_full Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation
title_fullStr Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation
title_full_unstemmed Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation
title_short Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation
title_sort silc1 long noncoding rna is an immediate-early gene promoting efficient memory formation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636608/
https://www.ncbi.nlm.nih.gov/pubmed/37742186
http://dx.doi.org/10.1016/j.celrep.2023.113168
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