High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling

Oxytocin-expressing paraventricular hypothalamic neurons (PVN(OT) neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVN(OT) neurons orchestrate gut-to-brain feeding control remain...

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Detalles Bibliográficos
Autores principales: Gruber, Tim, Lechner, Franziska, Murat, Cahuê, Contreras, Raian E., Sanchez-Quant, Eva, Miok, Viktorian, Makris, Konstantinos, Le Thuc, Ophélia, González-García, Ismael, García-Clave, Elena, Althammer, Ferdinand, Krabichler, Quirin, DeCamp, Lisa M., Jones, Russell G., Lutter, Dominik, Williams, Rhiannan H., Pfluger, Paul T., Müller, Timo D., Woods, Stephen C., Pospisilik, John Andrew, Martinez-Jimenez, Celia P., Tschöp, Matthias H., Grinevich, Valery, García-Cáceres, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636643/
https://www.ncbi.nlm.nih.gov/pubmed/37864798
http://dx.doi.org/10.1016/j.celrep.2023.113305

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