Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells

BACKGROUND: Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral arterial disease (PAD), is associated with a 1-year limb amputation rate of approximately 15–20% and substantial mortality. A key feature of CLTI is the compromised regenerative ability of skeletal muscle; how...

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Detalles Bibliográficos
Autores principales: Southerland, Kevin W., Xu, Yueyuan, Peters, Derek T., Lin, Xin, Wei, Xiaolin, Xiang, Yu, Fei, Kaileen, Olivere, Lindsey A., Morowitz, Jeremy M., Otto, James, Dai, Qunsheng, Kontos, Christopher D., Diao, Yarui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636829/
https://www.ncbi.nlm.nih.gov/pubmed/37950327
http://dx.doi.org/10.1186/s13073-023-01250-y

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