Transcription dosage compensation does not occur in Down syndrome

BACKGROUND: The increase in DNA copy number in Down syndrome (DS; caused by trisomy 21) has led to the DNA dosage hypothesis, which posits that the level of gene expression is proportional to the gene’s DNA copy number. Yet many reports have suggested that a proportion of chromosome 21 genes are dos...

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Detalles Bibliográficos
Autores principales: Hunter, Samuel, Hendrix, Jo, Freeman, Justin, Dowell, Robin D., Allen, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636926/
https://www.ncbi.nlm.nih.gov/pubmed/37946204
http://dx.doi.org/10.1186/s12915-023-01700-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636926/
https://www.ncbi.nlm.nih.gov/pubmed/37946204
http://dx.doi.org/10.1186/s12915-023-01700-4

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