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Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study
BACKGROUND: Prior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrolled hypertension as well as arterial stiffness among individuals with hypertens...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637002/ https://www.ncbi.nlm.nih.gov/pubmed/37946205 http://dx.doi.org/10.1186/s12933-023-02038-5 |
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author | Tan, Liao Liu, Yubo Liu, Jie Zhang, Guogang Liu, Zhaoya Shi, Ruizheng |
author_facet | Tan, Liao Liu, Yubo Liu, Jie Zhang, Guogang Liu, Zhaoya Shi, Ruizheng |
author_sort | Tan, Liao |
collection | PubMed |
description | BACKGROUND: Prior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrolled hypertension as well as arterial stiffness among individuals with hypertension remains undisclosed. METHODS: In this study, a total of 8513 adults diagnosed with hypertension from the National Health and Nutrition Examination Survey 1999–2018 were included. The primary outcome of the study are arterial stiffness (represented with estimated pulse wave velocity, ePWV) and uncontrolled hypertension. Logistic regression model, subgroup analysis, restricted cubic spine, and smooth curve fitting curve were conducted to evaluate the association between the IR indicators and uncontrolled hypertension and arterial stiffness in individuals with hypertension. RESULTS: Among included participants, the overall prevalence of uncontrolled hypertension was 54.3%. After adjusting for all potential covariates, compared with the first quartile of TyG index, the risk of uncontrolled hypertension increased about 28% and 49% for participants in the third quartile (OR, 1.28; 95% CI 1.06–1.52) and the fourth quartile (OR, 1.49; 95% CI 1.21–1.89) of TyG index, respectively. The higher OR of TyG index was observed in participants taking antihypertensive medication [fourth quartile versus first quartile (OR, 2.03; 95% CI 1.37–3.11)]. Meanwhile, we explored the potential association between TyG index and arterial stiffness and found that TyG index was significantly associated with increased arterial stiffness (β for ePWV, 0.04; 95% CI 0.00–0.08; P = 0.039). However, traditional IR indicator HOMA-IR showed no significant positive correlation to uncontrolled hypertension as well as arterial stiffness in US adults with hypertension. CONCLUSION: Elevated levels of the TyG index were positive associated with prevalence of uncontrolled hypertension and arterial stiffness among US adults with hypertension. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-023-02038-5. |
format | Online Article Text |
id | pubmed-10637002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106370022023-11-11 Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study Tan, Liao Liu, Yubo Liu, Jie Zhang, Guogang Liu, Zhaoya Shi, Ruizheng Cardiovasc Diabetol Research BACKGROUND: Prior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrolled hypertension as well as arterial stiffness among individuals with hypertension remains undisclosed. METHODS: In this study, a total of 8513 adults diagnosed with hypertension from the National Health and Nutrition Examination Survey 1999–2018 were included. The primary outcome of the study are arterial stiffness (represented with estimated pulse wave velocity, ePWV) and uncontrolled hypertension. Logistic regression model, subgroup analysis, restricted cubic spine, and smooth curve fitting curve were conducted to evaluate the association between the IR indicators and uncontrolled hypertension and arterial stiffness in individuals with hypertension. RESULTS: Among included participants, the overall prevalence of uncontrolled hypertension was 54.3%. After adjusting for all potential covariates, compared with the first quartile of TyG index, the risk of uncontrolled hypertension increased about 28% and 49% for participants in the third quartile (OR, 1.28; 95% CI 1.06–1.52) and the fourth quartile (OR, 1.49; 95% CI 1.21–1.89) of TyG index, respectively. The higher OR of TyG index was observed in participants taking antihypertensive medication [fourth quartile versus first quartile (OR, 2.03; 95% CI 1.37–3.11)]. Meanwhile, we explored the potential association between TyG index and arterial stiffness and found that TyG index was significantly associated with increased arterial stiffness (β for ePWV, 0.04; 95% CI 0.00–0.08; P = 0.039). However, traditional IR indicator HOMA-IR showed no significant positive correlation to uncontrolled hypertension as well as arterial stiffness in US adults with hypertension. CONCLUSION: Elevated levels of the TyG index were positive associated with prevalence of uncontrolled hypertension and arterial stiffness among US adults with hypertension. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-023-02038-5. BioMed Central 2023-11-09 /pmc/articles/PMC10637002/ /pubmed/37946205 http://dx.doi.org/10.1186/s12933-023-02038-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Tan, Liao Liu, Yubo Liu, Jie Zhang, Guogang Liu, Zhaoya Shi, Ruizheng Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
title | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
title_full | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
title_fullStr | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
title_full_unstemmed | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
title_short | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
title_sort | association between insulin resistance and uncontrolled hypertension and arterial stiffness among us adults: a population-based study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637002/ https://www.ncbi.nlm.nih.gov/pubmed/37946205 http://dx.doi.org/10.1186/s12933-023-02038-5 |
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