Improving combination therapies: targeting A(2B)-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression

BACKGROUND: We investigated the role of A(2B)-adenosine receptor in regulating immunosuppressive metabolic stress in the tumor microenvironment. Novel A(2B)-adenosine receptor antagonist PBF-1129 was tested for antitumor activity in mice and evaluated for safety and immunologic efficacy in a phase I...

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Detalles Bibliográficos
Autores principales: Evans, Jason V, Suman, Shankar, Goruganthu, Mounika Uttam L, Tchekneva, Elena E, Guan, Shuxiao, Arasada, Rajeswara Rao, Antonucci, Anneliese, Piao, Longzhu, Ilgisonis, Irina, Bobko, Andrey A, Driesschaert, Benoit, Uzhachenko, Roman V, Hoyd, Rebecca, Samouilov, Alexandre, Amann, Joseph, Wu, Ruohan, Wei, Lai, Pallerla, Aaditya, Ryzhov, Sergey V, Feoktistov, Igor, Park, Kyungho P, Kikuchi, Takefumi, Castro, Julio, Ivanova, Alla V, Kanagasabai, Thanigaivelan, Owen, Dwight H, Spakowicz, Daniel J, Zweier, Jay L, Carbone, David P, Novitskiy, Sergey V, Khramtsov, Valery V, Shanker, Anil, Dikov, Mikhail M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637048/
https://www.ncbi.nlm.nih.gov/pubmed/37195421
http://dx.doi.org/10.1093/jnci/djad091

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