Cholesterol biogenesis is a PTEN‐dependent actionable node for the treatment of endocrine therapy‐refractory cancers

PTEN and PIK3CA mutations are the most prevalent PI3K pathway alterations in prostate, breast, colorectal, and endometrial cancers. p110β becomes the prominent PI3K isoform upon PTEN loss. In this study, we aimed to understand the molecular mechanisms of PI3K dependence in the absence of PTEN. Using...

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Detalles Bibliográficos
Autores principales: Kaysudu, Irmak, Gungul, Taha Bugra, Atici, Sena, Yilmaz, Sevval, Bayram, Engin, Guven, Gozde, Cizmecioglu, Nihal Terzi, Sahin, Ozgur, Yesiloz, Gurkan, Haznedaroglu, Berat Zeki, Cizmecioglu, Onur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637061/
https://www.ncbi.nlm.nih.gov/pubmed/37706278
http://dx.doi.org/10.1111/cas.15960

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