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Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain
Human immunodeficiency virus-1 (HIV)-associated chronic pain is a debilitating comorbid condition that affects 25–85% of people with HIV. The use of opioids to alleviate pain has given rise to opioid dependency in this cohort. Therefore, there is an urgent need to understand mechanisms and identify...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637165/ https://www.ncbi.nlm.nih.gov/pubmed/37902051 http://dx.doi.org/10.1177/17448069231213554 |
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author | E Gryshyna, Anastasiia Chatterjee, Tanima J DeBerry, Jennifer Aggarwal, Saurabh |
author_facet | E Gryshyna, Anastasiia Chatterjee, Tanima J DeBerry, Jennifer Aggarwal, Saurabh |
author_sort | E Gryshyna, Anastasiia |
collection | PubMed |
description | Human immunodeficiency virus-1 (HIV)-associated chronic pain is a debilitating comorbid condition that affects 25–85% of people with HIV. The use of opioids to alleviate pain has given rise to opioid dependency in this cohort. Therefore, there is an urgent need to understand mechanisms and identify novel therapeutics for HIV-associated chronic pain. Several animal models have been developed to study HIV-related comorbidities. HIV-1 transgenic (Tg) rats have been shown to serve as a reliable model that mimic the deficits observed in people with HIV, such as neurological and immune system alterations. However, pain-related behavior in these animals has not been extensively evaluated. In this study, we measured evoked and spontaneous behavior in HIV-1Tg male and female rats. The results indicated that HIV-1Tg rats exhibit similar behavior to those with HIV-1-related neuropathy, specifically, cold sensitivity. Consequently, HIV-1Tg rats can serve as a model of neuropathy to study pain-related mechanisms and therapeutics targeted toward individuals living with HIV-1. |
format | Online Article Text |
id | pubmed-10637165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-106371652023-11-11 Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain E Gryshyna, Anastasiia Chatterjee, Tanima J DeBerry, Jennifer Aggarwal, Saurabh Mol Pain Research Article Human immunodeficiency virus-1 (HIV)-associated chronic pain is a debilitating comorbid condition that affects 25–85% of people with HIV. The use of opioids to alleviate pain has given rise to opioid dependency in this cohort. Therefore, there is an urgent need to understand mechanisms and identify novel therapeutics for HIV-associated chronic pain. Several animal models have been developed to study HIV-related comorbidities. HIV-1 transgenic (Tg) rats have been shown to serve as a reliable model that mimic the deficits observed in people with HIV, such as neurological and immune system alterations. However, pain-related behavior in these animals has not been extensively evaluated. In this study, we measured evoked and spontaneous behavior in HIV-1Tg male and female rats. The results indicated that HIV-1Tg rats exhibit similar behavior to those with HIV-1-related neuropathy, specifically, cold sensitivity. Consequently, HIV-1Tg rats can serve as a model of neuropathy to study pain-related mechanisms and therapeutics targeted toward individuals living with HIV-1. SAGE Publications 2023-11-09 /pmc/articles/PMC10637165/ /pubmed/37902051 http://dx.doi.org/10.1177/17448069231213554 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Article E Gryshyna, Anastasiia Chatterjee, Tanima J DeBerry, Jennifer Aggarwal, Saurabh Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain |
title | Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain |
title_full | Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain |
title_fullStr | Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain |
title_full_unstemmed | Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain |
title_short | Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain |
title_sort | assessment of pain-related behaviors in hiv-1 transgenic rats as a model of hiv-associated chronic pain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637165/ https://www.ncbi.nlm.nih.gov/pubmed/37902051 http://dx.doi.org/10.1177/17448069231213554 |
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