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Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids

The endoplasmic reticulum (ER)–embedded transcription factors, sterol regulatory element-binding proteins (SREBPs), master regulators of lipid biosynthesis, are transported to the Golgi for proteolytic activation to tune cellular cholesterol levels and regulate lipogenesis. However, mechanisms by wh...

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Detalles Bibliográficos
Autores principales:	Han, Song-Iee, Nakakuki, Masanori, Nakagawa, Yoshimi, Wang, Yunong, Araki, Masaya, Yamamoto, Yuta, Tokiwa, Hiroaki, Takeda, Hiroyuki, Mizunoe, Yuhei, Motomura, Kaori, Ohno, Hiroshi, Kainoh, Kenta, Murayama, Yuki, Aita, Yuichi, Takeuchi, Yoshinori, Osaki, Yoshinori, Miyamoto, Takafumi, Sekiya, Motohiro, Matsuzaka, Takashi, Yahagi, Naoya, Sone, Hirohito, Daitoku, Hiroaki, Sato, Ryuichiro, Kawano, Hiroyuki, Shimano, Hitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637267/ https://www.ncbi.nlm.nih.gov/pubmed/37954160 http://dx.doi.org/10.1093/pnasnexus/pgad351

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