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Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

BACKGROUND: The COVID-19 epidemic is a rapidly shifting situation that has resulted in significant regulatory reforms and widespread initiatives to deal with the initial crisis and its effects. The COVID-19 pandemic has had a significant impact on transplantation activities. The COVID-19 pandemic ha...

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Autores principales: Kidane, Kal, Alemu, Zewdie Aderaw, Biratu, Tolesa Diriba, Juhar, Leja Hamza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637368/
https://www.ncbi.nlm.nih.gov/pubmed/37954659
http://dx.doi.org/10.2147/IJGM.S423805
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author Kidane, Kal
Alemu, Zewdie Aderaw
Biratu, Tolesa Diriba
Juhar, Leja Hamza
author_facet Kidane, Kal
Alemu, Zewdie Aderaw
Biratu, Tolesa Diriba
Juhar, Leja Hamza
author_sort Kidane, Kal
collection PubMed
description BACKGROUND: The COVID-19 epidemic is a rapidly shifting situation that has resulted in significant regulatory reforms and widespread initiatives to deal with the initial crisis and its effects. The COVID-19 pandemic has had a significant impact on transplantation activities. The COVID-19 pandemic has caused various important challenges in the kidney transplant industry. OBJECTIVE: To identify the factors influencing COVID-19 severity in kidney transplant and non-kidney transplant patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. METHODS: A comparative cross-sectional study was conducted. This study included 364 patients (182 kidney transplants and 182 non-kidney transplants). A systematic random sampling was used to select the respondents. Professional nurses collected data for this study using a data extraction tools. Data were analyzed by using SPSS version 25 software. A multivariable logistic regression analysis was performed to identify the association between independent variables and COVID-19 severity with adjusted odds ratio (AOR), and 95% CI for AOR and P-value for testing significance. RESULTS: This study included 364 patients. Off the total, 34.1% developed severe COVID-19. In Multivariable logistic regression analysis, patients with 60 years and above age groups (AOR = 4.73; 95% CI: 1.86, 12.02), aged 40–59 years (AOR = 2.70; 95% CI: 1.17, 6.22), chest congestion (AOR = 4.49; 95% CI: 2.37, 8.50), history of muscle or body aches (AOR = 0.47; 95% CI: 0.22, 0.99) shortness of breath (AOR = 3.03; 95% CI: 1.36, 6.74), changed or lost sense of taste or smell (AOR = 2.77; 95% CI: 1.34, 5.71), and muscle pain (AOR = 3.05; 95% CI: 1.40, 6.65) were significant variables associated with COVID-19 severity after adjusting for other variables. CONCLUSION: The study revealed that 34.1% of patients had severe COVID-19. The majority of these patients underwent non-kidney transplants. Age groups and symptoms, such as chest congestion, shortness of breath, changed or lost sense of taste or smell, and muscle pain, were significant predictors of COVID-19 disease severity.
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spelling pubmed-106373682023-11-11 Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia Kidane, Kal Alemu, Zewdie Aderaw Biratu, Tolesa Diriba Juhar, Leja Hamza Int J Gen Med Original Research BACKGROUND: The COVID-19 epidemic is a rapidly shifting situation that has resulted in significant regulatory reforms and widespread initiatives to deal with the initial crisis and its effects. The COVID-19 pandemic has had a significant impact on transplantation activities. The COVID-19 pandemic has caused various important challenges in the kidney transplant industry. OBJECTIVE: To identify the factors influencing COVID-19 severity in kidney transplant and non-kidney transplant patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. METHODS: A comparative cross-sectional study was conducted. This study included 364 patients (182 kidney transplants and 182 non-kidney transplants). A systematic random sampling was used to select the respondents. Professional nurses collected data for this study using a data extraction tools. Data were analyzed by using SPSS version 25 software. A multivariable logistic regression analysis was performed to identify the association between independent variables and COVID-19 severity with adjusted odds ratio (AOR), and 95% CI for AOR and P-value for testing significance. RESULTS: This study included 364 patients. Off the total, 34.1% developed severe COVID-19. In Multivariable logistic regression analysis, patients with 60 years and above age groups (AOR = 4.73; 95% CI: 1.86, 12.02), aged 40–59 years (AOR = 2.70; 95% CI: 1.17, 6.22), chest congestion (AOR = 4.49; 95% CI: 2.37, 8.50), history of muscle or body aches (AOR = 0.47; 95% CI: 0.22, 0.99) shortness of breath (AOR = 3.03; 95% CI: 1.36, 6.74), changed or lost sense of taste or smell (AOR = 2.77; 95% CI: 1.34, 5.71), and muscle pain (AOR = 3.05; 95% CI: 1.40, 6.65) were significant variables associated with COVID-19 severity after adjusting for other variables. CONCLUSION: The study revealed that 34.1% of patients had severe COVID-19. The majority of these patients underwent non-kidney transplants. Age groups and symptoms, such as chest congestion, shortness of breath, changed or lost sense of taste or smell, and muscle pain, were significant predictors of COVID-19 disease severity. Dove 2023-11-06 /pmc/articles/PMC10637368/ /pubmed/37954659 http://dx.doi.org/10.2147/IJGM.S423805 Text en © 2023 Kidane et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Kidane, Kal
Alemu, Zewdie Aderaw
Biratu, Tolesa Diriba
Juhar, Leja Hamza
Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
title Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
title_full Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
title_fullStr Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
title_full_unstemmed Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
title_short Factors Associated with COVID-19 Severity Among Kidney Transplant and Non-Kidney Transplant Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
title_sort factors associated with covid-19 severity among kidney transplant and non-kidney transplant patients at st. paul’s hospital millennium medical college, addis ababa, ethiopia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637368/
https://www.ncbi.nlm.nih.gov/pubmed/37954659
http://dx.doi.org/10.2147/IJGM.S423805
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