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Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis

OBJECTIVE: To investigate brain structural and functional characteristics of three brain functional networks including default mode network (DMN), central executive network (CEN), and salience network (SN) in persistent negative symptoms (PNS) patients. METHODS: We performed an activation likelihood...

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Autores principales: Zhu, Tingting, Wang, Zengxiu, Wu, Weifeng, Ling, Yuru, Wang, Zixu, Zhou, Chao, Fang, Xinyu, Huang, Chengbing, Xie, Chunming, Chen, Jiu, Zhang, Xiangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637389/
https://www.ncbi.nlm.nih.gov/pubmed/37954938
http://dx.doi.org/10.3389/fnhum.2023.1204632
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author Zhu, Tingting
Wang, Zengxiu
Wu, Weifeng
Ling, Yuru
Wang, Zixu
Zhou, Chao
Fang, Xinyu
Huang, Chengbing
Xie, Chunming
Chen, Jiu
Zhang, Xiangrong
author_facet Zhu, Tingting
Wang, Zengxiu
Wu, Weifeng
Ling, Yuru
Wang, Zixu
Zhou, Chao
Fang, Xinyu
Huang, Chengbing
Xie, Chunming
Chen, Jiu
Zhang, Xiangrong
author_sort Zhu, Tingting
collection PubMed
description OBJECTIVE: To investigate brain structural and functional characteristics of three brain functional networks including default mode network (DMN), central executive network (CEN), and salience network (SN) in persistent negative symptoms (PNS) patients. METHODS: We performed an activation likelihood estimation (ALE) meta-analysis of functional connectivity (FC) studies and voxel-based morphometry (VBM) studies to detect specific structural and functional alterations of brain networks between PNS patients and healthy controls. RESULTS: Seventeen VBM studies and twenty FC studies were included. In the DMN, PNS patients showed decreased gray matter in the bilateral medial frontal gyrus and left anterior cingulate gyrus and a significant reduction of FC in the right precuneus. Also, PNS patients had a decrease of gray matter in the left inferior parietal lobules and medial frontal gyrus, and a significant reduction of FC in the bilateral superior frontal gyrus in the CEN. In comparison with healthy controls, PNS patients exhibited reduced gray matter in the bilateral insula, anterior cingulate gyrus, left precentral gyrus and right claustrum and lower FC in these brain areas in the SN, including the left insula, claustrum, inferior frontal gyrus and extra-nuclear. CONCLUSION: This meta-analysis reveals brain structural and functional imaging alterations in the three networks and the interaction among these networks in PNS patients, which provides neuroscientific evidence for more personalized treatment. Systematic Review RegistrationThe PROSPERO (https://www.crd.york.ac.uk/PROSPERO/, registration number: CRD42022335962).
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spelling pubmed-106373892023-11-11 Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis Zhu, Tingting Wang, Zengxiu Wu, Weifeng Ling, Yuru Wang, Zixu Zhou, Chao Fang, Xinyu Huang, Chengbing Xie, Chunming Chen, Jiu Zhang, Xiangrong Front Hum Neurosci Human Neuroscience OBJECTIVE: To investigate brain structural and functional characteristics of three brain functional networks including default mode network (DMN), central executive network (CEN), and salience network (SN) in persistent negative symptoms (PNS) patients. METHODS: We performed an activation likelihood estimation (ALE) meta-analysis of functional connectivity (FC) studies and voxel-based morphometry (VBM) studies to detect specific structural and functional alterations of brain networks between PNS patients and healthy controls. RESULTS: Seventeen VBM studies and twenty FC studies were included. In the DMN, PNS patients showed decreased gray matter in the bilateral medial frontal gyrus and left anterior cingulate gyrus and a significant reduction of FC in the right precuneus. Also, PNS patients had a decrease of gray matter in the left inferior parietal lobules and medial frontal gyrus, and a significant reduction of FC in the bilateral superior frontal gyrus in the CEN. In comparison with healthy controls, PNS patients exhibited reduced gray matter in the bilateral insula, anterior cingulate gyrus, left precentral gyrus and right claustrum and lower FC in these brain areas in the SN, including the left insula, claustrum, inferior frontal gyrus and extra-nuclear. CONCLUSION: This meta-analysis reveals brain structural and functional imaging alterations in the three networks and the interaction among these networks in PNS patients, which provides neuroscientific evidence for more personalized treatment. Systematic Review RegistrationThe PROSPERO (https://www.crd.york.ac.uk/PROSPERO/, registration number: CRD42022335962). Frontiers Media S.A. 2023-10-26 /pmc/articles/PMC10637389/ /pubmed/37954938 http://dx.doi.org/10.3389/fnhum.2023.1204632 Text en Copyright © 2023 Zhu, Wang, Wu, Ling, Wang, Zhou, Fang, Huang, Xie, Chen and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Zhu, Tingting
Wang, Zengxiu
Wu, Weifeng
Ling, Yuru
Wang, Zixu
Zhou, Chao
Fang, Xinyu
Huang, Chengbing
Xie, Chunming
Chen, Jiu
Zhang, Xiangrong
Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis
title Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis
title_full Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis
title_fullStr Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis
title_full_unstemmed Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis
title_short Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis
title_sort altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637389/
https://www.ncbi.nlm.nih.gov/pubmed/37954938
http://dx.doi.org/10.3389/fnhum.2023.1204632
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