Cargando…

Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital

The coronavirus disease-2019 (COVID-19) infection has taken the world by storm within a few months. Evidence has suggested that patients with electrolyte imbalances at baseline may have a longer duration of hospital stay. We aimed to determine the factors associated with hyponatremia on admission in...

Descripción completa

Detalles Bibliográficos
Autores principales: Rehman, Fazal ur, Rehan, Syeda Tayyaba, Rind, Bakhtawar Jamal, Valliani, Komal, Asghar, Muhammad Sohaib, Omair, Farrukh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637499/
https://www.ncbi.nlm.nih.gov/pubmed/37960743
http://dx.doi.org/10.1097/MD.0000000000035920
_version_ 1785146511130099712
author Rehman, Fazal ur
Rehan, Syeda Tayyaba
Rind, Bakhtawar Jamal
Valliani, Komal
Asghar, Muhammad Sohaib
Omair, Farrukh
author_facet Rehman, Fazal ur
Rehan, Syeda Tayyaba
Rind, Bakhtawar Jamal
Valliani, Komal
Asghar, Muhammad Sohaib
Omair, Farrukh
author_sort Rehman, Fazal ur
collection PubMed
description The coronavirus disease-2019 (COVID-19) infection has taken the world by storm within a few months. Evidence has suggested that patients with electrolyte imbalances at baseline may have a longer duration of hospital stay. We aimed to determine the factors associated with hyponatremia on admission in COVID-19 patients and its impact on the length of stay. We conducted a retrospective study including 521 patients who tested positive for COVID-19 and had their electrolytes checked on admission from June 2020 to October 2020. Patients with sodium <135 mmol/l were included in the hyponatremic group and were compared against normonatremic patients. The severity of COVID-19 was found to be more prevalent in the case group as compared to control (38.3% vs 29.2%; 21.1% vs 17.7%). Hyponatremic patients stayed more than 5 days in hospital (56.3% vs 46.5%), and stayed longer in special care (23.4% vs 20.0%) as compared to controls. Hyponatremic patients as compared to control were more likely to have diabetes (47.9% vs 30.0%), hypertension (49.0% vs 38.5%), ischemic heart disease (20.7% vs 15.4%), chronic liver disease (2.7% vs 1.2%), and chronic kidney disease (9.6% vs 3.8%). Upon matching on the age, the adjusted odds of hyponatremia in COVID-19-positive patients were 1.9 times among diabetic patients. Moreover, COVID-19-positive patients suffering from CKD had a higher risk of developing hyponatremia (OR = 2.3, 95% CI: 1.1–5.6). The risk of hyponatremia among COVID-19-positive patients is statistically higher in patients with 1 comorbidity (OR = 1.9, 95%CI: 1.3–3.4). Hyponatremia on admission can be used to forecast the length of hospital stay and the severity of illness in COVID-19 patients.
format Online
Article
Text
id pubmed-10637499
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-106374992023-11-15 Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital Rehman, Fazal ur Rehan, Syeda Tayyaba Rind, Bakhtawar Jamal Valliani, Komal Asghar, Muhammad Sohaib Omair, Farrukh Medicine (Baltimore) 4900 The coronavirus disease-2019 (COVID-19) infection has taken the world by storm within a few months. Evidence has suggested that patients with electrolyte imbalances at baseline may have a longer duration of hospital stay. We aimed to determine the factors associated with hyponatremia on admission in COVID-19 patients and its impact on the length of stay. We conducted a retrospective study including 521 patients who tested positive for COVID-19 and had their electrolytes checked on admission from June 2020 to October 2020. Patients with sodium <135 mmol/l were included in the hyponatremic group and were compared against normonatremic patients. The severity of COVID-19 was found to be more prevalent in the case group as compared to control (38.3% vs 29.2%; 21.1% vs 17.7%). Hyponatremic patients stayed more than 5 days in hospital (56.3% vs 46.5%), and stayed longer in special care (23.4% vs 20.0%) as compared to controls. Hyponatremic patients as compared to control were more likely to have diabetes (47.9% vs 30.0%), hypertension (49.0% vs 38.5%), ischemic heart disease (20.7% vs 15.4%), chronic liver disease (2.7% vs 1.2%), and chronic kidney disease (9.6% vs 3.8%). Upon matching on the age, the adjusted odds of hyponatremia in COVID-19-positive patients were 1.9 times among diabetic patients. Moreover, COVID-19-positive patients suffering from CKD had a higher risk of developing hyponatremia (OR = 2.3, 95% CI: 1.1–5.6). The risk of hyponatremia among COVID-19-positive patients is statistically higher in patients with 1 comorbidity (OR = 1.9, 95%CI: 1.3–3.4). Hyponatremia on admission can be used to forecast the length of hospital stay and the severity of illness in COVID-19 patients. Lippincott Williams & Wilkins 2023-11-10 /pmc/articles/PMC10637499/ /pubmed/37960743 http://dx.doi.org/10.1097/MD.0000000000035920 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4900
Rehman, Fazal ur
Rehan, Syeda Tayyaba
Rind, Bakhtawar Jamal
Valliani, Komal
Asghar, Muhammad Sohaib
Omair, Farrukh
Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital
title Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital
title_full Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital
title_fullStr Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital
title_full_unstemmed Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital
title_short Hyponatremia causing factors and its association with disease severity and length of stay in COVID-19 patients: A retrospective study from tertiary care hospital
title_sort hyponatremia causing factors and its association with disease severity and length of stay in covid-19 patients: a retrospective study from tertiary care hospital
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637499/
https://www.ncbi.nlm.nih.gov/pubmed/37960743
http://dx.doi.org/10.1097/MD.0000000000035920
work_keys_str_mv AT rehmanfazalur hyponatremiacausingfactorsanditsassociationwithdiseaseseverityandlengthofstayincovid19patientsaretrospectivestudyfromtertiarycarehospital
AT rehansyedatayyaba hyponatremiacausingfactorsanditsassociationwithdiseaseseverityandlengthofstayincovid19patientsaretrospectivestudyfromtertiarycarehospital
AT rindbakhtawarjamal hyponatremiacausingfactorsanditsassociationwithdiseaseseverityandlengthofstayincovid19patientsaretrospectivestudyfromtertiarycarehospital
AT vallianikomal hyponatremiacausingfactorsanditsassociationwithdiseaseseverityandlengthofstayincovid19patientsaretrospectivestudyfromtertiarycarehospital
AT asgharmuhammadsohaib hyponatremiacausingfactorsanditsassociationwithdiseaseseverityandlengthofstayincovid19patientsaretrospectivestudyfromtertiarycarehospital
AT omairfarrukh hyponatremiacausingfactorsanditsassociationwithdiseaseseverityandlengthofstayincovid19patientsaretrospectivestudyfromtertiarycarehospital