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Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis

BACKGROUND: Cardiovascular disease (CVD) is a common complication of rheumatoid arthritis (RA). We aimed to explore the risk factors for cardiovascular disease in patients with rheumatoid arthritis and provide a scientific basis on effective prevention and treatments for CVD in RA patients. METHODS:...

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Autores principales: Lyu, Qian, Ma, Linxiao, Liu, Huijie, Wang, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637523/
https://www.ncbi.nlm.nih.gov/pubmed/37960768
http://dx.doi.org/10.1097/MD.0000000000035912
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author Lyu, Qian
Ma, Linxiao
Liu, Huijie
Wang, Jihong
author_facet Lyu, Qian
Ma, Linxiao
Liu, Huijie
Wang, Jihong
author_sort Lyu, Qian
collection PubMed
description BACKGROUND: Cardiovascular disease (CVD) is a common complication of rheumatoid arthritis (RA). We aimed to explore the risk factors for cardiovascular disease in patients with rheumatoid arthritis and provide a scientific basis on effective prevention and treatments for CVD in RA patients. METHODS: We searched for a combination of the subject words and free words involved arthritis, rheumatoid, CVD, heart disease, vascular disease, risk factors, etc. from China Knowledge Network, Wanfang, Vip, China Biomedical Literature Database, Pubmed, Embase, Web of Science, Cochrane and other databases for documents published in public in 2000-October 2022.RevMan 5.3 and Stata14.0 analysis software was used to perform a meta-analysis of case-control and cohort studies on risk factors of CVDs in patients with RA published from 2000 to 2022.The Egger method was used to determine whether there was publication bias. RESULTS: Seventeen pieces of literature were included in this meta-analysis. We explored the associations between CVD and different clinical characters such as DAS28 score, rheumatoid factor, triglyceride, age, sex, C-reactive protein, total cholesterol (TC), hypertension, and D dimer. High serum levels of C-reactive protein, TC, and D-dimer, as well as hypertension, are the main risk factors for CVD in patients with RA. The OR and 95% CI of C-reactive protein were 2.06 (1.91–2.23), RR and 95% CI of TC were 1.7 (1.49–1.93), RR and 95% CI of hypertension were 3.58 (2.37–5.40), as well as OR and 95% CI of D dimer were 2.83 (1.48–5.40).Our results performed by the meta-analysis were reliable, with low publication bias existed. CONCLUSION: C-reactive protein, TC, hypertension, and D dimer are the main risk factors for CVD in patients with RA. No protective factors were found.
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spelling pubmed-106375232023-11-15 Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis Lyu, Qian Ma, Linxiao Liu, Huijie Wang, Jihong Medicine (Baltimore) 6900 BACKGROUND: Cardiovascular disease (CVD) is a common complication of rheumatoid arthritis (RA). We aimed to explore the risk factors for cardiovascular disease in patients with rheumatoid arthritis and provide a scientific basis on effective prevention and treatments for CVD in RA patients. METHODS: We searched for a combination of the subject words and free words involved arthritis, rheumatoid, CVD, heart disease, vascular disease, risk factors, etc. from China Knowledge Network, Wanfang, Vip, China Biomedical Literature Database, Pubmed, Embase, Web of Science, Cochrane and other databases for documents published in public in 2000-October 2022.RevMan 5.3 and Stata14.0 analysis software was used to perform a meta-analysis of case-control and cohort studies on risk factors of CVDs in patients with RA published from 2000 to 2022.The Egger method was used to determine whether there was publication bias. RESULTS: Seventeen pieces of literature were included in this meta-analysis. We explored the associations between CVD and different clinical characters such as DAS28 score, rheumatoid factor, triglyceride, age, sex, C-reactive protein, total cholesterol (TC), hypertension, and D dimer. High serum levels of C-reactive protein, TC, and D-dimer, as well as hypertension, are the main risk factors for CVD in patients with RA. The OR and 95% CI of C-reactive protein were 2.06 (1.91–2.23), RR and 95% CI of TC were 1.7 (1.49–1.93), RR and 95% CI of hypertension were 3.58 (2.37–5.40), as well as OR and 95% CI of D dimer were 2.83 (1.48–5.40).Our results performed by the meta-analysis were reliable, with low publication bias existed. CONCLUSION: C-reactive protein, TC, hypertension, and D dimer are the main risk factors for CVD in patients with RA. No protective factors were found. Lippincott Williams & Wilkins 2023-11-10 /pmc/articles/PMC10637523/ /pubmed/37960768 http://dx.doi.org/10.1097/MD.0000000000035912 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 6900
Lyu, Qian
Ma, Linxiao
Liu, Huijie
Wang, Jihong
Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis
title Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis
title_full Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis
title_fullStr Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis
title_full_unstemmed Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis
title_short Meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis
title_sort meta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis
topic 6900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637523/
https://www.ncbi.nlm.nih.gov/pubmed/37960768
http://dx.doi.org/10.1097/MD.0000000000035912
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