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Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory

To explore the mechanism of Tripterygium wilfordii polyglycoside (TWP) in the treatment of membranous nephropathy (MN) by network pharmacology. TCMSP and DrugBank databases were used to screen the main targets of the main active components of Tripterygium glycosides, and OMIM and Gene Cards database...

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Detalles Bibliográficos
Autores principales: Xu, Pengyu, Fu, Guangchu, Zhao, Haishen, Wang, Manya, Ye, Hong, Shi, Kejun, Zang, Pin, Su, Xubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637535/
https://www.ncbi.nlm.nih.gov/pubmed/37960769
http://dx.doi.org/10.1097/MD.0000000000034686
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author Xu, Pengyu
Fu, Guangchu
Zhao, Haishen
Wang, Manya
Ye, Hong
Shi, Kejun
Zang, Pin
Su, Xubo
author_facet Xu, Pengyu
Fu, Guangchu
Zhao, Haishen
Wang, Manya
Ye, Hong
Shi, Kejun
Zang, Pin
Su, Xubo
author_sort Xu, Pengyu
collection PubMed
description To explore the mechanism of Tripterygium wilfordii polyglycoside (TWP) in the treatment of membranous nephropathy (MN) by network pharmacology. TCMSP and DrugBank databases were used to screen the main targets of the main active components of Tripterygium glycosides, and OMIM and Gene Cards databases were used to search the gene targets of MN. UniProt database was used to normalize all the targets to get the intersection targets of TGs and MNs. Synergistic genes were uploaded to the STRING platform to construct a protein-protein interaction network and screen related core targets. Gene Ontology and Kyoto Genome Encyclopedia analyses of core targets were performed using the DAVID database. AutoDockTools software was used to verify the molecular docking between the active components of TGs and the synergistic genes. We identified 126 potential targets for the active component of Tripterygium glycosides, 584 MN-associated disease targets, and 28 co-acting genes. It mainly involves AGE-RAGE signaling pathway, lipid and atherosclerosis, IL-17 signaling pathway, fluid shear stress and atherosclerosis, NF-kappa B signaling pathway and other pathways and biological pathways in diabetic complications. The active component of that Tripterygium glycosides and the active site of the synergistic core target can the bond energy is less than −5kJ/mol. Tripterygium glycosides can regulate the release of inflammatory factors to treat MN through multiple active components, multiple disease targets, multiple biological pathways and multiple pathways, which provides a basis for broadening the clinical use of traditional Chinese medicine in the treatment of MN.
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spelling pubmed-106375352023-11-15 Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory Xu, Pengyu Fu, Guangchu Zhao, Haishen Wang, Manya Ye, Hong Shi, Kejun Zang, Pin Su, Xubo Medicine (Baltimore) 5200 To explore the mechanism of Tripterygium wilfordii polyglycoside (TWP) in the treatment of membranous nephropathy (MN) by network pharmacology. TCMSP and DrugBank databases were used to screen the main targets of the main active components of Tripterygium glycosides, and OMIM and Gene Cards databases were used to search the gene targets of MN. UniProt database was used to normalize all the targets to get the intersection targets of TGs and MNs. Synergistic genes were uploaded to the STRING platform to construct a protein-protein interaction network and screen related core targets. Gene Ontology and Kyoto Genome Encyclopedia analyses of core targets were performed using the DAVID database. AutoDockTools software was used to verify the molecular docking between the active components of TGs and the synergistic genes. We identified 126 potential targets for the active component of Tripterygium glycosides, 584 MN-associated disease targets, and 28 co-acting genes. It mainly involves AGE-RAGE signaling pathway, lipid and atherosclerosis, IL-17 signaling pathway, fluid shear stress and atherosclerosis, NF-kappa B signaling pathway and other pathways and biological pathways in diabetic complications. The active component of that Tripterygium glycosides and the active site of the synergistic core target can the bond energy is less than −5kJ/mol. Tripterygium glycosides can regulate the release of inflammatory factors to treat MN through multiple active components, multiple disease targets, multiple biological pathways and multiple pathways, which provides a basis for broadening the clinical use of traditional Chinese medicine in the treatment of MN. Lippincott Williams & Wilkins 2023-11-10 /pmc/articles/PMC10637535/ /pubmed/37960769 http://dx.doi.org/10.1097/MD.0000000000034686 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5200
Xu, Pengyu
Fu, Guangchu
Zhao, Haishen
Wang, Manya
Ye, Hong
Shi, Kejun
Zang, Pin
Su, Xubo
Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory
title Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory
title_full Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory
title_fullStr Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory
title_full_unstemmed Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory
title_short Review of molecular biological research on the treatment of membranous nephropathy with Tripterygium glycosides based on TCM theory
title_sort review of molecular biological research on the treatment of membranous nephropathy with tripterygium glycosides based on tcm theory
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637535/
https://www.ncbi.nlm.nih.gov/pubmed/37960769
http://dx.doi.org/10.1097/MD.0000000000034686
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