Cargando…

Distinct functions and transcriptional signatures in orally induced regulatory T cell populations

Oral administration of antigen induces regulatory T cells (Treg) that can not only control local immune responses in the small intestine, but also traffic to the central immune system to deliver systemic suppression. Employing murine models of the inherited bleeding disorder hemophilia, we find that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biswas, Moanaro, So, Kaman, Bertolini, Thais B., Krishnan, Preethi, Rana, Jyoti, Muñoz-Melero, Maite, Syed, Farooq, Kumar, Sandeep R. P., Gao, Hongyu, Xuei, Xiaoling, Terhorst, Cox, Daniell, Henry, Cao, Sha, Herzog, Roland W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637621/ https://www.ncbi.nlm.nih.gov/pubmed/37954612 http://dx.doi.org/10.3389/fimmu.2023.1278184

Ejemplares similares

Treg: tolerance vs immunity
por: Biswas, Moanaro, et al.
Publicado: (2015)

Gene Therapy With Regulatory T Cells: A Beneficial Alliance
por: Biswas, Moanaro, et al.
Publicado: (2018)

Reprogrammed CD4(+) T Cells That Express FoxP3(+) Control Inhibitory Antibody Formation in Hemophilia A Mice
por: Herzog, Roland W., et al.
Publicado: (2019)

CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII
por: Rana, Jyoti, et al.
Publicado: (2021)

Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia
por: Kumar, Sandeep R. P., et al.
Publicado: (2020)

B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin
por: Biswas, Moanaro, et al.
Publicado: (2020)

Dynamics of antigen presentation to transgene product-specific CD4(+) T cells and of Treg induction upon hepatic AAV gene transfer
por: Perrin, George Q, et al.
Publicado: (2016)

Expression and assembly of largest foreign protein in chloroplasts: oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in haemophilia A mice
por: Kwon, Kwang‐Chul, et al.
Publicado: (2017)

Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A
por: Sherman, Alexandra, et al.
Publicado: (2017)

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia
por: Sarkar, Debalina, et al.
Publicado: (2014)

Clinical development of gene therapy: results and lessons from recent successes
por: Kumar, Sandeep RP, et al.
Publicado: (2016)

Preclinical development of plant‐based oral immune modulatory therapy for haemophilia B
por: Srinivasan, Aparajitha, et al.
Publicado: (2021)

Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity
por: Biswas, Moanaro, et al.
Publicado: (2020)

Immune Modulatory Cell Therapy for Hemophilia B Based on CD20-Targeted Lentiviral Gene Transfer to Primary B Cells
por: Wang, Xiaomei, et al.
Publicado: (2017)

Factor VIII trafficking to CD4(+) T cells shapes its immunogenicity and requires several types of antigen-presenting cells
por: Kaczmarek, Radoslaw, et al.
Publicado: (2023)

Single-dose AAV vector gene immunotherapy to treat food allergy
por: Gonzalez-Visiedo, Miguel, et al.
Publicado: (2022)

B cell–activating factor modulates the factor VIII immune response in hemophilia A
por: Doshi, Bhavya S., et al.
Publicado: (2021)

Exploring breast tissue microbial composition and the association with breast cancer risk factors
por: German, Rana, et al.
Publicado: (2023)

Development of gene transfer for induction of antigen-specific tolerance
por: Sack, Brandon K, et al.
Publicado: (2014)

Immune Responses to Viral Gene Therapy Vectors
por: Shirley, Jamie L., et al.
Publicado: (2020)

Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes
por: Krishnan, Preethi, et al.
Publicado: (2019)

Gene Therapy Research at the Frontiers of Viral Immunology
por: Hoffman, Brad E., et al.
Publicado: (2012)

Plant cell-made protein antigens for induction of Oral tolerance
por: Daniell, Henry, et al.
Publicado: (2019)

Effect of CpG Depletion of Vector Genome on CD8(+) T Cell Responses in AAV Gene Therapy
por: Bertolini, Thais B., et al.
Publicado: (2021)

A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection
por: Rawson, Ashley, et al.
Publicado: (2022)

38766 Massively Parallel Reporter Assay Reveals Functional Impact of 3™-UTR SNPs Associated with Neurological and Psychiatric Disorders
por: Chen, Andy B., et al.
Publicado: (2021)

The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline
por: Janosevic, Danielle, et al.
Publicado: (2021)

Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
por: Saxena, Vijay, et al.
Publicado: (2021)

Statistical modeling for sensitive detection of low-frequency single nucleotide variants
por: Hao, Yangyang, et al.
Publicado: (2016)

The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease
por: Wang, Ninghai, et al.
Publicado: (2019)

Osteogenic Differentiation Potential of Mesenchymal Stem Cells Using Single Cell Multiomic Analysis
por: Chen, Duojiao, et al.
Publicado: (2023)

Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity
por: Martino, Ashley T., et al.
Publicado: (2009)

Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells
por: Liao, Gongxian, et al.
Publicado: (2014)

A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells
por: Bhat-Nakshatri, Poornima, et al.
Publicado: (2021)

Cryopreservation Preserves Cell-Type Composition and Gene Expression Profiles in Bone Marrow Aspirates From Multiple Myeloma Patients
por: Chen, Duojiao, et al.
Publicado: (2021)

Intratumoural administration and tumour tissue targeting of cancer immunotherapies
por: Melero, Ignacio, et al.
Publicado: (2021)

Evaluation of deoxypyridinoline levels in gingival crevicular fluid and serum as alveolar bone loss biomarker in patients with periodontitis
por: Syed, Suhail, et al.
Publicado: (2020)

Responses to Microbial Challenges by SLAMF Receptors
por: van Driel, Boaz Job, et al.
Publicado: (2016)

CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function
por: Jain, Nidhi, et al.
Publicado: (2017)

The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics
por: Krishnan, Preethi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jfh8j89q1im19c1d8v6ffokl24