Cognitive impairment in long-living adults: a genome-wide association study, polygenic risk score model and molecular modeling of the APOE protein

BACKGROUND: Cognitive impairment is an irreversible, aging-associated condition that robs people of their independence. The purpose of this study was to investigate possible causes of this condition and propose preventive options. METHODS: We assessed cognitive status in long-living adults aged 90+...

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Detalles Bibliográficos
Autores principales: Kashtanova, D. A., Mamchur, A. A., Dzhumaniyazova, I. H., Ivanov, M. V., Erema, V. V., Zelenova, E. A., Yakovchik, A. Y., Gusakova, M. S., Rumyantseva, A. M., Terekhov, M. V., Matkava, L. R., Akopyan, A. A., Strazhesko, I. D., Yudin, V. S., Makarov, V. V., Kraevoy, S. A., Tkacheva, O. N., Yudin, S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637623/
https://www.ncbi.nlm.nih.gov/pubmed/37953886
http://dx.doi.org/10.3389/fnagi.2023.1273825

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