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Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans

Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However, the mechanisms that regulate sphingolipid catabolism are not known. Here we characterize a transcriptional axis that regulates sphingolipid breakdown to control resistance against bac...

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Detalles Bibliográficos
Autores principales: Nasrallah, Mohamad A., Peterson, Nicholas D., Szumel, Elizabeth S., Liu, Pengpeng, Page, Amanda L., Tse, Samantha Y., Wani, Khursheed A., Tocheny, Claire E., Pukkila-Worley, Read
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637724/
https://www.ncbi.nlm.nih.gov/pubmed/37906605
http://dx.doi.org/10.1371/journal.ppat.1011730